An Enantiomer-Selective Liquid Chromatography-Tandem Mass Spectrometry Method for Methadone and EDDP Validated for Use in Human Plasma, Urine, and Liver Microsomes
- Author
- MOODY, David E1 ; LIN, Shen-Nan1 ; YAN CHANG1 ; LAMM, Lolita1 ; GREENWALD, Mark K2 ; AHMED, Mahmoud S3
[1] Center for Human Toxicology, Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah 84108, United States
[2] Substance Abuse Research Division, Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, Michigan 48207, United States
[3] Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, Texas 77555, United States - Source
Journal of analytical toxicology. 2008, Vol 32, Num 3, pp 208-219, 12 p ; ref : 57 ref
- CODEN
- JATOD3
- ISSN
- 0146-4760
- Scientific domain
- Toxicology
- Publisher
- Preston, Niles, IL
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Analgésique narcotique Analyse chimique Analyse quantitative Chromatographie HPLC Electrospray Enantiomère Extraction liquide liquide Extraction solvant Foie Glycoprotéine acide α1 Homme Liquide biologique Microsome Méthadone Méthode couplée Pharmacocinétique Phase stationnaire chirale Plasma sanguin Protéine sérique Préparation échantillon Sang Séparation Tissu Urine Validation Voie orale LC MS MS Pyrrolidine(1,5-diméthyl-3,3-diméthyl-2-éthylidène) Spectrométrie masse tandem Opiacés
- Keyword (en)
- Narcotic analgesic Chemical analysis Quantitative analysis HPLC chromatography Electrospray Enantiomer Liquid liquid extraction Solvent extraction Liver α1-acid-Glycoprotein Human Biological fluid Microsome Methadone Coupled method Pharmacokinetics Chiral stationary phase Blood plasma Serum protein Sample preparation Blood Separation Tissue Urine Validation Oral administration Tandem mass spectrometry Opiates
- Keyword (es)
- Analgésico narcotico Análisis químico Análisis cuantitativo Cromatografía HPLC Electrospray Enantiómero Extracción líquido líquido Extracción solvente Hígado Glicoproteína ácida α1 Hombre Líquido biológico Microsoma Metadona Método acoplado Farmacocinética Fase estacionaria quiral Plasma sanguíneo Proteína sérica Preparación muestreo Sangre Separación Tejido Orina Validación Vía oral Espectrometría masa en tándem Opiados
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02A General pharmacology / 002B02A02 Analysis
- Discipline
- General pharmacology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 20209970
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1093/jat/32.3.208 
https://dx.doi.org/10.1093/jat/32.3.208
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