Stereospecific synthesis and bio-activity of novel β3-adrenoceptor agonists and inverse agonists
- Author
- GRAZIA PERRONE, Maria1 ; SANTANDREA, Ernesto1 ; BLEVE, Laura1 ; VITALE, Paola1 ; COLABUFO, Nicola Antonio1 ; JOCKERS, Ralf2 ; MILAZZO, Ferdinando Maria3 ; SCIARRONI, Anna Floriana3 ; SCILIMATI, Antonio1
[1] Dipartimento Farmaco-Chimico, Università di Bari, Via E. Orabona 4, 70125 Bari, Italy
[2] Institut Cochin Inserm U567, CNRS 8104, Universite Paris, Descartes 22 rue Méchain, 75014 Paris, France
[3] Dipartimento di Endocrinologia e Metaholismo, Sigma-Tau S.p.A, Via Pontina km 30.400, 00040 Pomezia, Italy - Source
Bioorganic & medicinal chemistry. 2008, Vol 16, Num 5, pp 2473-2488, 16 p ; ref : 53 ref
- ISSN
- 0968-0896
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier Science, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Author keyword
- (αS Agonist Anxiety and depressive disorders Cachexia DELFIA Heart failure Inverse agonist Metabolic syndrome Obesity Overactive bladder Preterm labour Type 2 diabetes β3-adrenoceptor βR)-2-{4-[2-(2-hydroxy-2-phenylethylamino)ethyl]phenoxy}propanoic acid βS- and αS
- Keyword (fr)
- Acide carboxylique Affinité Agoniste inverse Agoniste Aminoalcool Diastéréoisomère Dérivé du benzène Enantiomère Homme In vitro Racémique Relation structure activité Récepteur β3-adrénergique Stimulant β-adrénergique Stéréospécificité Synthèse chimique Propionique acide2-[4-(2-[(β-hydroxyphénéthyl)amino]éthyl)phénoxy] Propionique acide2-[4-(2-[(β-hydroxyphénéthyl)amino]éthyl)phénoxy]-2-méthyl
- Keyword (en)
- Carboxylic acid Affinity Inverse agonist Agonist Aminoalcohol Diastereomer Benzene derivatives Enantiomer Human In vitro Racemic Structure activity relation β3-Adrenergic receptor β-Adrenergic receptor agonist Stereospecificity Chemical synthesis
- Keyword (es)
- Acido carboxílico Afinidad Agonista inversa Agonista Aminoalcohol Diasteréomero Benceno derivado Enantiómero Hombre In vitro Racémico Relación estructura actividad Receptor β3-adrenérgico Estimulante β-adrenérgico Estereoespecificidad Síntesis química
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02B Neuropharmacology / 002B02B09 Neurotransmitters. Neurotransmission. Receptors / 002B02B09A Catecholaminergic system
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 20218970
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmc.2007.11.060 
https://dx.doi.org/10.1016/j.bmc.2007.11.060
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