A novel synthesis and pharmacological evaluation of a potential dopamine D1/D2 agonist : 1-Propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinoline-6,7-diol
- Author
- DANYANG LIU1 ; DIJKSTRA, Durk1 ; DE VRIES, Jan B1 ; WIKSTRÖM, Hakan V1
[1] Department of Medicinal Chemistry, University Centre for Pharmacy, University of Groningen, Antonius Deusinglaan 1, 9713 A V Groningen, Netherlands - Source
Bioorganic & medicinal chemistry. 2008, Vol 16, Num 6, pp 3438-3444, 7 p ; ref : 26 ref
- ISSN
- 0968-0896
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier Science, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Author keyword
- Catecholamine Enone prodrug Microdialysis Parkinson's disease
- Keyword (fr)
- Activité biologique Affinité Agoniste Amine biogène Animal Antiparkinsonien Catécholamine Composé aromatique Composé tricyclique Diphénols Dopamine Hétérocycle azote In vitro In vivo Microdialyse Neurotransmetteur Rat Récepteur dopaminergique D1 Récepteur dopaminergique D2 Synthèse chimique Voie orale Benzo[g]quinoléine-6,7-diol(octahydro-1-propyl) Benzoquinoléine TL 334 Mammalia Rodentia Vertebrata
- Keyword (en)
- Biological activity Affinity Agonist Biogenic amine Animal Antiparkinson agent Catecholamine Aromatic compound Tricyclic compound Diphenols Dopamine Nitrogen heterocycle In vitro In vivo Microdialysis Neurotransmitter Rat D1 Dopamine receptor D2 Dopamine receptor Chemical synthesis Oral administration Mammalia Rodentia Vertebrata
- Keyword (es)
- Actividad biológica Afinidad Agonista Amina biógena Animal Antiparkinsoniano Catecolamina Compuesto aromático Compuesto tricíclico Difenoles Dopamina Heterociclo nitrógeno In vitro In vivo Microdiálisis Neurotransmisor Rata Receptor dopaminérgico D1 Receptor dopaminérgico D2 Síntesis química Vía oral Mammalia Rodentia Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02B Neuropharmacology / 002B02B06 Anticonvulsants. Antiepileptics. Antiparkinson agents
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02B Neuropharmacology / 002B02B09 Neurotransmitters. Neurotransmission. Receptors / 002B02B09A Catecholaminergic system
- Discipline
- Pharmacological treatments Psychopathology. Psychiatry. Clinical psychology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 20226149
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmc.2007.06.036 
https://dx.doi.org/10.1016/j.bmc.2007.06.036
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