Synthesis, anti-HIV-1 activity, and modeling studies of N-3 Boc TSAO compound
- Author
- TOMASSI, Cyrille1 ; VAN NHIEN, Albert Nguyen1 ; MARCO-CONTELLES, José2 ; BALZARINI, Jan3 ; PANNECOUQUE, Christophe3 ; DE CLERCQ, Erik3 ; SORIANO, Elena4 ; POSTEL, Denis1
[1] Laboratoire des Glucides (UMR6219), Université de Picardie Jules Verne, 33 rue Saint Leu, 80039 Amiens, France
[2] Laboratorio de Radicales Libres (IQOG, CSIC), CIJuan de la Cierva, 3, 28006 Madrid, Spain
[3] Rega Institute for Medical Research, Katholieke Universiteit Leuven, 3000 Leuven, Belgium
[4] Laboratorio de Resonancia Magnetica (IIB, CSIC), ClArturo Duperier 4, 28029 Madrid, Spain - Source
Bioorganic & medicinal chemistry letters (Print). 2008, Vol 18, Num 7, pp 2277-2281, 5 p ; ref : 17 ref
- ISSN
- 0960-894X
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Author keyword
- ATSAO Aminonitrile CSIC reaction Computational study NNRTI TSAO
- Keyword (fr)
- Activité biologique Antiviral Carbanion Composé non nucléoside Cyclisation Hétérocycle oxygène soufre Inhibiteur enzyme Inhibiteur reverse transcriptase Mode liaison Modèle moléculaire Modélisation RNA-directed DNA polymerase Réaction intramoléculaire Silicium Composé organique Simulation ordinateur Spirane Sulfonate Sultone Synthèse chimique Virus HIV1 1,7-Dioxa-2-thiaspiro[4.4]non-3-ène(4-amino-8-[3-(t-butoxycarbonyl)-1-thymyl]-6,9-bis-[t-butyldiméthylsiloxy]) 1,7-Dioxa-2-thiaspiro[4.4]nonane dérivé Anti hiv TSAO Enzyme Lentivirus Nucleotidyltransferases Retroviridae Transferases Virus immunodéficience humaine Virus
- Keyword (en)
- Biological activity Antiviral Carbanion Non nucleoside compound Cyclization Oxygen sulfur heterocycle Enzyme inhibitor Reverse transcriptase inhibitor Binding mode Molecular model Modeling RNA-directed DNA polymerase Intramolecular reaction Silicon Organic compounds Computer simulation Spiran Sulfonate Sultone Chemical synthesis HIV-1 virus Enzyme Lentivirus Nucleotidyltransferases Retroviridae Transferases Human immunodeficiency virus Virus
- Keyword (es)
- Actividad biológica Antiviral Carbanión Compuesto no nucleósido Ciclización Heterociclo oxígeno azufre Inhibidor enzima Inhibitor reverse transcriptase Modo de enlace Modelo molecular Modelización RNA-directed DNA polymerase Reacción intramolecular Silicio Compuesto orgánico Simulación computadora Espirano Sulfonato Sultona Síntesis química HIV-1 virus Enzima Lentivirus Nucleotidyltransferases Retroviridae Transferases Human immunodeficiency virus Virus
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02S Antibiotics. Antiinfectious agents. Antiparasitic agents / 002B02S05 Antiviral agents
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 20253527
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmcl.2008.03.010 
https://dx.doi.org/10.1016/j.bmcl.2008.03.010
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