TIE-2/VEGF-R2 SAR and in vitro activity of C3-acyl dihydroindazolo[5,4-a]pyrrolo[3,4-c]carbazole analogs
- Author
- UNDERINER, Ted L1 ; RUGGERI, Bruce1 ; WEINBERG, Linda1 ; SHI YANG1 ; ZULLI, Allison1 ; AIMONE, Lisa1 ; ALBOM, Mark1 ; ANGELES, Thelma1 ; HONG CHANG1 ; HUDKINS, Robert L1 ; HUNTER, Kathryn1 ; JOSEF, Kurt1 ; ROBINSON, Candy1
[1] Cephalon, Inc., 145 Brandywine Parkway, West Chester, PA 19380-4245, United States - Source
Bioorganic & medicinal chemistry letters (Print). 2008, Vol 18, Num 7, pp 2368-2372, 5 p ; ref : 14 ref
- ISSN
- 0960-894X
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Author keyword
- Anti- angiogenic Kinase inhibitor TIE-2 VEGF-R2 VEGFR2
- Keyword (fr)
- Angiogenèse Animal Antiangiogénique Anticancéreux Aorte Biodisponibilité Dérivé du thiophène Facteur angiogène Facteur croissance endothélium vasculaire In vitro In vivo Inhibiteur Lactame Modèle moléculaire Modélisation Néovascularisation Pharmacocinétique Rat Relation dose réponse Relation structure activité Synthèse chimique Transduction signal Transferases Vascularisation Voie intraveineuse Voie orale Indazolo[5,4-a]pyrrolo[3,4-c]carbazole dérivé Indazolopyrrolocarbazole Receptor protein-tyrosine kinase VEGFR2 Enzyme Mammalia Rodentia Vertebrata
- Keyword (en)
- Angiogenesis Animal Antiangiogenic agent Antineoplastic agent Aorta Bioavailability Thiophene derivatives Angiogenic factor Vascular endothelium growth factor In vitro In vivo Inhibitor Lactam Molecular model Modeling Neovascularization Pharmacokinetics Rat Dose activity relation Structure activity relation Chemical synthesis Signal transduction Transferases Vascularization Intravenous administration Oral administration Enzyme Mammalia Rodentia Vertebrata
- Keyword (es)
- Angiogénesis Animal Antiangiogenico Anticanceroso Aorta Biodisponibilidad Tiofeno derivado Factor angiógeno Factor crecimiento endotelio vascular In vitro In vivo Inhibidor Lactamo Modelo molecular Modelización Neovascularización Farmacocinética Rata Relación dosis respuesta Relación estructura actividad Síntesis química Transducción señal Transferases Vascularización Vía intravenosa Vía oral Enzima Mammalia Rodentia Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R01 General aspects
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 20253546
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmcl.2008.02.069 
https://dx.doi.org/10.1016/j.bmcl.2008.02.069
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