A novel selective peroxisome proliferator-activator receptor-γ modulator : SPPARγM5 improves insulin sensitivity with diminished adverse cardiovascular effects
- Author
- CHANG, Ching H1 ; MCNAMARA, Lesley A1 ; MCCANN, Margaret E1 ; WU, Margaret S2 ; MUISE, Eric S3 ; YEJUN TAN4 ; WOOD, Harold B5 ; MEINKE, Peter T5 ; THOMPSON, John R3 ; DOEBBER, Tom W2 ; BERGER, Joel P2
[1] Department of Pharmacology, Merck Research Laboratories, P.O. Box 2000, RY80Y-140, Rahway, NJ, 07065, United States
[2] Department of Metabolic Disorders, Merck Research Laboratories, P.O. Box 2000, RY80M-136, Rahway, NJ, 07065, United States
[3] Department of Molecular Profiling, Merck Research Laboratories, P.O. Box 2000, RY80M-162, Rahway, NJ, 07065, United States
[4] Informatics, Rosetta Inpharmatics LLC, a wholly owned subsidiary of Merck & Co., Inc, Seattle, WA, 98109, United States
[5] Department of Medicinal Chemistry, Merck Research Laboratories, P.O. Box 2000, RY800-B101, Rahway, NJ, 07065, United States - Source
European journal of pharmacology. 2008, Vol 584, Num 1, pp 192-201, 10 p ; ref : 1 p.1/4
- CODEN
- EJPHAZ
- ISSN
- 0014-2999
- Scientific domain
- Pharmacology drugs
- Publisher
- Elsevier, Amsterdam
- Publication country
- Netherlands
- Document type
- Article
- Language
- English
- Author keyword
- Adverse cardiovascular effects Insulin sensitizer Selective PPARγ modulators
- Keyword (fr)
- Appareil circulatoire Chimiosensibilisant Insuline Proliférateur peroxysome Récepteur PPAR-γ Récepteur biologique Sensibilité Toxicité Hormone pancréatique
- Keyword (en)
- Circulatory system Chemosensitizing agent Insulin Peroxisome proliferator PPAR-γ receptor Biological receptor Sensitivity Toxicity Pancreatic hormone
- Keyword (es)
- Aparato circulatorio Quimiosensibilizante Insulina Proliferador peroxisoma Receptor PPAR-γ Receptor biológico Sensibilidad Toxicidad Hormona pancreática
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments
- Discipline
- General pharmacology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 20253937
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.ejphar.2007.12.036 
https://dx.doi.org/10.1016/j.ejphar.2007.12.036
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