A novel sesquiterpene lactone from Centaurea pullata : Structure elucidation, antimicrobial activity, and prediction of pharmacokinetic properties
- Author
- DJEDDI, Samah1 ; KARIOTI, Anastasia1 ; SOKOVIC, Marina2 ; KOUKOULITSA, Catherine3 ; SKALTSA, Helen1
[1] Department of Pharmacognosy and Chemistry of Natural Products, School of Pharmacy, University of Athens, Panepistimiopolis, Zografou, 157 71 Athens, Greece
[2] Department of Plant Physiology, Mycological Laboratory, Institute for Biological Research, 29 Novembar 142, 11 000 Belgrade, Serbia
[3] Institute of Organic and Pharmaceutical Chemistry, National Hellenic Research Foundation, Vas. Constantinou 48, 11635 Athens, Greece - Source
Bioorganic & medicinal chemistry. 2008, Vol 16, Num 7, pp 3725-3731, 7 p ; ref : 38 ref
- ISSN
- 0968-0896
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier Science, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Author keyword
- 8α-O-(4-Hydroxy-2-methylenebutanoyloxy)melitensine ADME Antibacterial activity Antifungal activity Centaurea pullata VolSurf
- Keyword (fr)
- Activité biologique Analyse structurale Antibactérien Antifongique Antimicrobien Barrière hématoencéphalique Compositae Côlon Homme Hydrosolubilité In vitro Isolement Lactone Lignée cellulaire Origine végétale Partie aérienne végétal Perméabilité cellulaire Pharmacocinétique Pharmacognosie Plante médicinale Propriété physicochimique Prédiction Sesquiterpène Terpénoïde ADME Centaurea pullata Elemane dérivé Elemanolide Lignée CACO2 Melitensine dérivé Angiospermae Dicotyledones Spermatophyta
- Keyword (en)
- Biological activity Structural analysis Antibacterial agent Antifungal agent Antimicrobial agent Blood brain barrier Compositae Colon Human Water solubility In vitro Isolation Lactone Cell line Plant origin Above ground plant part Cell permeability Pharmacokinetics Pharmacognosy Medicinal plant Physicochemical properties Prediction Sesquiterpenes Terpenoid Absorption Distribution Metabolisme Excretion Angiospermae Dicotyledones Spermatophyta
- Keyword (es)
- Actividad biológica Análisis estructural Antibacteriano Antifúngico Antimicrobiano Barrera hematoencefálica Compositae Colón Hombre Hidrosolubilidad In vitro Aislamiento Lactona Línea celular Origen vegetal Parte aérea vegetal Permeabilidad celular Farmacocinética Farmacognosia Planta medicinal Propiedad fisicoquímica Predicción Sesquiterpeno Terpenoide Angiospermae Dicotyledones Spermatophyta
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02A General pharmacology / 002B02A04 Pharmacognosy. Homeopathy. Health food
- Discipline
- General pharmacology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 20272629
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmc.2008.01.056 
https://dx.doi.org/10.1016/j.bmc.2008.01.056
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