A pharmacokinetic and pharmacodynamic study on metronomic irinotecan in metastatic colorectal cancer patients
- Author
- ALLEGRINI, G1 ; FALCONE, A1 ; DANESI, R2 ; DEL TACCA, M2 ; BOCCI, G2 ; FIORAVANTI, A2 ; BARLETTA, M. T1 ; ORLANDI, P2 ; LOUPAKIS, F1 ; CERRI, E1 ; MASI, G1 ; DI PAOLO, A2 ; KERBEL, R. S3 4
[1] Division of Medical Oncology, General Hospital of Livorno, Department Of Oncology, University of Pisa, Pisa, Italy
[2] Division of Pharmacology and Chemotherapy, Department of Internal Medicine, University of Pisa, Pisa, Italy
[3] Molecular and Cellular Biology Research, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
[4] Deportment of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada - Source
British journal of cancer. 2008, Vol 98, Num 8, pp 1312-1319, 8 p ; ref : 1 p.1/4
- CODEN
- BJCAAI
- ISSN
- 0007-0920
- Scientific domain
- Medical oncology
- Publisher
- Nature Publishing Group, Basingstoke
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Author keyword
- angiogenesis clinical study colon cancer irinotecan metronomic chemotherapy thrombospondin-I
- Keyword (fr)
- Angiogenèse Anticancéreux Cancer colorectal Cancer du côlon Cancérologie Homme Irinotécan Métastase Néovascularisation Pharmacocinétique Stade avancé Thrombospondine Chimiothérapie métronomique Pharmacodynamie Camptothécine dérivé Cancer DNA topoisomerase Enzyme Inhibiteur de la topoisomérase I Inhibiteur enzyme Isomerases Pathologie de l'appareil digestif Pathologie de l'intestin Pathologie du côlon Pathologie du rectum Tumeur maligne
- Keyword (en)
- Angiogenesis Antineoplastic agent Colorectal cancer Colon cancer Cancerology Human Irinotecan Metastasis Neovascularization Pharmacokinetics Advanced stage Thrombospondin Metronomic chemotherapy Pharmacodynamics Camptothecin derivatives Cancer DNA topoisomerase Enzyme Topoisomerase I inhibitor Enzyme inhibitor Isomerases Digestive diseases Intestinal disease Colonic disease Rectal disease Malignant tumor
- Keyword (es)
- Angiogénesis Anticanceroso Cancer de colon y recto Cáncer del colon Cancerología Hombre Irinotecán Metástasis Neovascularización Farmacocinética Estadio avanzado Trombospondina Farmacodinámica Camptothecin derivado Cáncer DNA topoisomerase Enzima Inhibidor topoisomerase I Inhibidor enzima Isomerases Aparato digestivo patología Intestino patología Colón patología Recto patología Tumor maligno
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B13 Gastroenterology. Liver. Pancreas. Abdomen / 002B13B Stomach. Duodenum. Small intestine. Colon. Rectum. Anus / 002B13B01 Tumors
- Discipline
- Gastroenterology. Liver. Pancreas. Abdomen Tumours
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 20283481
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1038/sj.bjc.6604311 
https://dx.doi.org/10.1038/sj.bjc.6604311
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