The Albumin Effect and in Vitro-in Vivo Extrapolation : Sequestration of Long-Chain Unsaturated Fatty Acids Enhances Phenytoin Hydroxylation by Human Liver Microsomal and Recombinant Cytochrome P450 2C9
- Author
- ROWLAND, Andrew1 ; ELLIOT, David J1 ; KNIGHTS, Kathleen M1 ; MACKENZIE, Peter I1 ; MINERS, John O1
[1] Department of Clinical Pharmacology, Flinders University and Flinders Medical Centre, Bedford Park, Adelaide, Australia - Source
Drug metabolism and disposition. 2008, Vol 36, Num 5, pp 870-877, 8 p ; ref : 3/4 p
- CODEN
- DMDSAI
- ISSN
- 0090-9556
- Scientific domain
- Pharmacology drugs
- Publisher
- American Society for Pharmacology and Experimental Therapeutics, Bethesda, MD
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Acide gras insaturé Albumine Chaîne longue Cytochrome P450 Extrapolation Foie Homme Hydroxylation In vitro In vivo Isozyme Microsome Phénytoïne Protéine recombinante Anticonvulsivant Appareil digestif Enzyme Lipide Métabolisme Pharmacocinétique
- Keyword (en)
- Unsaturated fatty acid Albumin Long chain Cytochrome P450 Extrapolation Liver Human Hydroxylation In vitro In vivo Isozyme Microsome Phenytoin Recombinant protein Anticonvulsant Digestive system Enzyme Lipids Metabolism Pharmacokinetics
- Keyword (es)
- Acido graso no saturado Albúmina Cadena larga Citocromo P450 Extrapolación Hígado Hombre Hidroxilación In vitro In vivo Isozima Microsoma Fenitoína Proteína recombinante Anticonvulsivante Aparato digestivo Enzima Lípido Metabolismo Farmacocinética
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments
- Discipline
- General pharmacology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 20291580
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1124/dmd.107.019885 
https://dx.doi.org/10.1124/dmd.107.019885
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