Akt activation protects pancreatic beta cells from AMPK-mediated death through stimulation of mTOR
- Author
- YING CAI1 ; QIDI WANG1 ; ZHIDONG LING1 ; PIPELEERS, Daniel1 ; MCDERMOTT, Paul2 3 ; PENDE, Mario4 ; HEIMBERG, Harry1 ; VAN DE CASTEELE, Mark1
[1] Diabetes Research Center, Brussels Free University, VUB, Partner of the Juvénile Diabetes Research Center for Beta Cell Therapy in Europe, Laarbeeklaan 103, 1090 Brussels, Belgium
[2] Department of Medicine, the Gazes Cardiac Research Institute, Medical University of South Carolina, United States
[3] Ralph H. Johnson Department of Veterans Affairs Medical Center, Charleston, SC 29403, United States
[4] Inserm, Avenir, U584, Université Paris 5, Faculté de Médecine Necker-Enfants Malades, 156 rue de Vaugirard, Paris 75730, France - Source
Biochemical pharmacology. 2008, Vol 75, Num 10, pp 1981-1993, 13 p ; ref : 54 ref
- CODEN
- BCPCA6
- ISSN
- 0006-2952
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs; Physiology, morphology
- Publisher
- Elsevier Science, New York, NY
- Publication country
- United States
- Document type
- Article
- Language
- English
- Author keyword
- AMPK Akt Apoptosis Beta cell Diabetes mTOR
- Keyword (fr)
- Akt protein kinase Apoptose Cellule β Diabète Mort cellulaire Protéine mTOR Prévention Stimulation cAMP-dependent protein kinase Protein kinase mTOR Endocrinopathie Pancréas endocrine
- Keyword (en)
- Akt protein kinase Apoptosis β Cell Diabetes mellitus Cell death Mammalian target of rapamycin Prevention Stimulation cAMP-dependent protein kinase Protein kinase mTOR Endocrinopathy Endocrine pancreas
- Keyword (es)
- Akt protein kinase Apoptosis Célula β Diabetes Muerte celular Proteína mTOR Prevención Estimulación cAMP-dependent protein kinase Endocrinopatía Páncreas endocrino
- Classification
- Pascal
- 002 Biological and medical sciences / 002A Fundamental and applied biological sciences. Psychology / 002A04 Molecular and cellular biology / 002A04H Cell physiology / 002A04H05 Ageing, cell death
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B21 Endocrinopathies / 002B21E Endocrine pancreas. Apud cells (diseases) / 002B21E01 Diabetes. Impaired glucose tolerance / 002B21E01A Etiopathogenesis. Screening. Investigations. Target tissue resistance
- Discipline
- Endocrinopathies Molecular and cell biology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 20317446
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bcp.2008.02.019 
https://dx.doi.org/10.1016/j.bcp.2008.02.019
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