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A novel pyrene-guanidiniocarbonyl-pyrrole cation efficiently differentiates between ds-DNA and ds-RNA by two independent, sensitive spectroscopic methods

Author
HERNANDEZ-FOLGADO, Laura1 ; SCHMUCK, Carsten1 ; TOMIC, Sanja2 ; PIANTANIDA, Ivo3
[1] Institut für Organische Chemie, Universität Würzburg, Am Hubland, 97074, Würzburg, Germany
[2] Laboratory for Chemical and Biological Crystallography, Ruder BoškoviĆ Institute, Zagreb, Croatia
[3] Laboratory for Supramolecular and Nucleoside Chemistry, Division of Organic Chemistry and Biochemistry, Ruder BoškoviĆ Institute POB 180, 10002 Zagreb, Croatia
Source

Bioorganic & medicinal chemistry letters (Print). 2008, Vol 18, Num 9, pp 2977-2981, 5 p ; ref : 12 ref

ISSN
0960-894X
Scientific domain
Biochemistry, molecular biology, biophysics; Pharmacology drugs
Publisher
Elsevier, Oxford
Publication country
United Kingdom
Document type
Article
Language
English
Author keyword
Guanidinium Pyrene Pyrrole ds-DNA ds-RNA
Keyword (fr)
Activité biologique Cation organique Composé du guanidinium DNA bicaténaire Fixation biologique Interaction moléculaire RNA bicaténaire Spectrométrie CD Spectrométrie fluorescence Synthèse chimique Guanidinium1-[5-([4-([pyrén-3-ylcarbonyl]amino)butyl]carbamoyl)pyrrole-2-carbonyl] Pyrrole-2-carboxamide dérivé Pyrène-3-carboxamide dérivé
Keyword (en)
Biological activity Organic cation Guanidinium compounds Double stranded DNA Biological fixation Molecular interaction Double stranded RNA Circular dichroism spectrometry Fluorescence spectrometry Chemical synthesis
Keyword (es)
Actividad biológica Catión orgánico Guanidinio compuesto DNA bicatenario Fijación biológica Interacción molecular ARN bicatenario Espectrometría CD Espectrometría fluorescencia Síntesis química
Classification
Pascal
002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R01 General aspects

Discipline
Pharmacological treatments
Origin
Inist-CNRS
Database
PASCAL
INIST identifier
20317713

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS

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