A potent and selective p38 inhibitor protects against bone damage in murine collagen-induced arthritis : a comparison with neutralization of mouse TNFα
- Author
- MIHARA, K1 ; ALMANSA, C2 ; NELISSEN, R. L1 ; SMEETS, R. L1 ; LOOMANS, E. E. M. G3 ; DULOS, J1 ; VINK, P. M. F1 ; ROOSEBOOM, M1 ; KREUTZER, H1 ; CAVALCANTI, F4 ; BOOTS, A. M1
[1] Department of Pharmacology, NV Organon, Oss, Netherlands
[2] Department of Medicinal Chemistry, Palau Pharma SA, Barcelona, Spain
[3] Department of Molecular Pharmacology, NV Organon, Oss, Netherlands
[4] Department of Discovery Biology, Palau Pharma SA, Barcelona, Spain - Source
British journal of pharmacology. 2008, Vol 154, Num 1, pp 153-164, 12 p ; ref : 1 p
- CODEN
- BJPCBM
- ISSN
- 0007-1188
- Scientific domain
- Pharmacology drugs
- Publisher
- Nature Publishing, Basingstoke
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Author keyword
- Org 48762-0 anti-TNFα therapy bone damage collagen-induced arthritis inflammation p38 MAPK proinflammatory cytokines rheumatoid arthritis
- Keyword (fr)
- Animal Anti-TNF-alpha Chronique Cytokine Etude comparative Facteur nécrose tumorale α Inflammation Inhibiteur Lésion Mitogen-activated protein kinase Neutralisation Os Polyarthrite rhumatoïde Prévention Souris Traitement p38 Mitogen activated protein kinase Enzyme Immunopathologie Maladie autoimmune Mammalia Pathologie du système ostéoarticulaire Rhumatisme inflammatoire Rodentia Système ostéoarticulaire Transferases Vertebrata
- Keyword (en)
- Animal Anti-Tumor Necrosis Factor-alpha Chronic Cytokine Comparative study Tumor necrosis factor α Inflammation Inhibitor Lesion Mitogen-activated protein kinase Neutralization Bone Rheumatoid arthritis Prevention Mouse Treatment p38 Mitogen activated protein kinase Enzyme Immunopathology Autoimmune disease Mammalia Diseases of the osteoarticular system Inflammatory joint disease Rodentia Osteoarticular system Transferases Vertebrata
- Keyword (es)
- Animal Anti-TNF alfa Crónico Citoquina Estudio comparativo Factor necrosis tumoral α Inflamación Inhibidor Lesión Mitogen-activated protein kinase Neutralización Hueso Poliartritis reumatoidea Prevención Ratón Tratamiento P38 Mitogen activated protein kinase Enzima Inmunopatología Enfermedad autoinmune Mammalia Sistema osteoarticular patología Reumatismo inflamatorio Rodentia Sistema osteoarticular Transferases Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B15 Diseases of the osteoarticular system / 002B15D Inflammatory joint diseases
- Discipline
- General pharmacology Osteoarticular pathology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 20337376
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1038/bjp.2008.53 
https://dx.doi.org/10.1038/bjp.2008.53
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