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Targeted Deletion of the Sclerostin Gene in Mice Results in Increased Bone Formation and Bone Strength

Author
XIAODONG LI1 ; OMINSKY, Michael S1 ; ASUNCION, Frank1 ; BARRERO, Mauricio1 ; WARMINGTON, Kelly1 ; DWYER, Denise1 ; STOLINA, Marina1 ; MORONY, Sean1 ; SAROSI, Ildiko3 ; KOSTENUIK, Paul J1 ; LACEY, David L1 ; SIMONET, W. Scott1 ; NIU, Qing-Tian1 ; HUA ZHU KE1 ; PASZTY, Chris1 ; NING SUN2 ; DAUGHERTY, Betsy2 ; D'AGOSTIN, Diane2 ; KURAHARA, Carole2 ; YONGMING GAO1 ; JIN CAO1 ; JIANHUA GONG1
[1] Department of Metabolic Disorders, Amgen, Thousand Oaks, California, United States
[2] Department of Protein Sciences, Amgen, Thousand Oaks, California, United States
[3] Department of Pathology, Amgen, Thousand Oaks, California, United States
Source

Journal of bone and mineral research (Print). 2008, Vol 23, Num 6, pp 860-869, 10 p ; ref : 29 ref

CODEN
JBMREJ
ISSN
0884-0431
Scientific domain
Cell biology, histology; Physiology, morphology; Rheumatology
Publisher
American Society for Bone and Mineral Research, Duham, NC
Publication country
United States
Document type
Article
Language
English
Author keyword
SOST bone formation bone strength sclerosteosis sclerostin
Keyword (fr)
Délétion Formation Gène Os Résistance mécanique Sclérostéose Souris Système ostéoarticulaire Mammalia Ostéochondrodysplasie Pathologie du système ostéoarticulaire Rodentia Vertebrata
Keyword (en)
Deletion Formation Gene Bone Strength Sclerosteosis Mouse Osteoarticular system Mammalia Osteochondrodysplasia Diseases of the osteoarticular system Rodentia Vertebrata
Keyword (es)
Deleción Formación Gen Hueso Resistencia mecánica Escleroesteosis Ratón Sistema osteoarticular Mammalia Osteocondrodisplasia Sistema osteoarticular patología Rodentia Vertebrata
Classification
Pascal
002 Biological and medical sciences / 002A Fundamental and applied biological sciences. Psychology / 002A23 Vertebrates: osteoarticular system, musculoskeletal system / 002A23A Skeleton and joints

Discipline
Vertebrates : osteoarticular system, musculoskeletal system
Origin
Inist-CNRS
Database
PASCAL
INIST identifier
20372918

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS

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