Aldehyde dehydrogenase inhibitors : α,β-Acetylenic N-substituted aminothiolesters are reversible growth inhibitors of normal epithelial but irreversible apoptogens for cancer epithelial cells from human prostate in culture
- Author
- QUASH, Gerard1 ; FOURNET, Guy2 ; REICHERT, Uwe4 ; COURVOISIER, Charlotte2 ; MARTINEZ, Rosa M2 ; CHANTEPIE, Jacqueline1 ; PARET, Marie Julie1 ; PHARABOZ, Julie3 ; ODILE JOLY-PHARABOZ, Marie3 ; GORE, Jacques2 ; ANDRE, Jean3
[1] Laboratoire d'Immunochimie, Faculté de médecine Lyon Sud, INSERM U-329, Oullins, 69621, France
[2] Laboratoire de Chimie Organique 1, CNRS UMR5246, CPE, Villeurbanne, 69622, France
[3] Hopital Debrousse, INSERM U-329, Lyon, 69322, France
[4] Galderma R & D, Route des luciolles, BP 87, 06902 Sophia Antipolis, Valbonne, France - Source
European journal of medicinal chemistry. 2008, Vol 43, Num 5, pp 906-916, 11 p ; ref : 28 ref
- CODEN
- EJMCA5
- ISSN
- 0223-5234
- Scientific domain
- Organic chemistry; Pharmacology drugs
- Publisher
- Elsevier, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Author keyword
- ALDH1 and ALDH3 inhibitors Acetylenic aminothiolesters Apoptosis Human prostate cancer cells Human prostate epithelial normal cells
- Keyword (fr)
- Aldehyde dehydrogenase [NAD-(P)+] Amine tertiaire Anticancéreux Apoptose Cellule tumorale Cellule épithéliale Composé acétylénique Composé aliphatique Cytotoxicité Dérivé de la morpholine Homme In vitro Inhibiteur enzyme Isozyme Lignée cellulaire Prostate Relation structure activité Synthèse chimique Sélectivité Thioester Toxicité Lignée DU145 Pent-2-ynethioïque acide(4-diméthylamino-4-méthyl) ester S-méthyle Pent-2-ynethioïque acide(4-méthyl-4-morpholino) ester S-méthyle Enzyme Oxidoreductases
- Keyword (en)
- Aldehyde dehydrogenase [NAD-(P)+] Tertiary amine Antineoplastic agent Apoptosis Tumor cell Epithelial cell Acetylenic compound Aliphatic compound Cytotoxicity Morpholine derivatives Human In vitro Enzyme inhibitor Isozyme Cell line Prostate Structure activity relation Chemical synthesis Selectivity Thioester Toxicity Enzyme Oxidoreductases
- Keyword (es)
- Aldehyde dehydrogenase [NAD-(P)+] Amina terciaria Anticanceroso Apoptosis Célula tumoral Célula epitelial Compuesto acetilénico Compuesto alifático Citotoxicidad Hombre In vitro Inhibidor enzima Isozima Línea celular Prostata Relación estructura actividad Síntesis química Selectividad Tioester Toxicidad Enzima Oxidoreductases
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R01 General aspects
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 20375045
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.ejmech.2007.06.004 
https://dx.doi.org/10.1016/j.ejmech.2007.06.004
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