Allosteric inhibitors of Aktl and Akt2 : A naphthyridinone with efficacy in an A2780 tumor xenograft model
- Author
- BILODEAU, Mark T1 ; BALITZA, Adrienne E1 ; SMITH, Anthony M1 ; HUBER, Hans E2 ; HARTMAN, George D1 ; HOFFMAN, Jacob M1 ; MANLEY, Peter J1 ; BARNETT, Stanley F2 ; DEFEO-JONES, Deborah2 ; HASKELL, Kathleen2 ; JONES, Raymond E2 ; LEANDER, Karen2 ; ROBINSON, Ronald G2
[1] Department of Medicinal Chemistry, Merck Research Laboratories, Merck & Co., PO Box 4, West Point, PA 19486, United States
[2] Department of Cancer Research, Merck Research Laboratories, Merck & Co., PO Box 4, West Point, PA 19486, United States - Source
Bioorganic & medicinal chemistry letters (Print). 2008, Vol 18, Num 11, pp 3178-3182, 5 p
- ISSN
- 0960-894X
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Author keyword
- Akt Oncology
- Keyword (fr)
- Akt protein kinase Animal Anticancéreux Cellule tumorale Dérivé de la naphtyridine Dérivé de la pipéridine Dérivé de la pyridine Homme In vitro In vivo Inhibiteur allostérique Inhibiteur enzyme Isozyme Lactame Lignée cellulaire Non-specific serine/threonine protein kinase Ovaire Relation structure activité Souris Synthèse chimique Transduction signal 1,2,4-Triazole dérivé 1,6-Naphtyridin-5-one dérivé 1,6-Naphtyridine dérivé Lignée A2780 Naphtyridinone dérivé Enzyme Mammalia Rodentia Transferases Vertebrata
- Keyword (en)
- Akt protein kinase Animal Antineoplastic agent Tumor cell Naphtyridine derivatives Piperidine derivatives Pyridine derivatives Human In vitro In vivo Allosteric inhibitor Enzyme inhibitor Isozyme Lactam Cell line Non-specific serine/threonine protein kinase Ovary Structure activity relation Mouse Chemical synthesis Signal transduction Enzyme Mammalia Rodentia Transferases Vertebrata
- Keyword (es)
- Akt protein kinase Animal Anticanceroso Célula tumoral Piperidina derivado Piridina derivado Hombre In vitro In vivo Inhibidor alostérico Inhibidor enzima Isozima Lactamo Línea celular Non-specific serine/threonine protein kinase Ovario Relación estructura actividad Ratón Síntesis química Transducción señal Enzima Mammalia Rodentia Transferases Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R01 General aspects
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 20411640
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmcl.2008.04.074 
https://dx.doi.org/10.1016/j.bmcl.2008.04.074
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