The SAR studies of novel CB2 selective agonists, benzimidazolone derivatives
- Author
- OMURA, Hirofumi1 ; KAWAI, Makoto1 ; KIKUCHI, Akira2 ; IWATA, Hiroshi2 ; ANDO, Kazuo1 ; SHIMA, Akiko1 ; IWATA, Yasuhiro1 ; ITO, Fumitaka1 ; MASUDA, Tsutomu1 ; OHTA, Atsuko1 ; MAKITA, Naoya1 ; OMOTO, Kiyoyuki1 ; SUGIMOTO, Hiromi2
[1] Discovery Chemistry Research, Pfizer Global Research & Development, Nagoya Laboratories, Pfizer Japan Inc, 5-2 Taketoyo, Aichi 470-2393, Japan
[2] Discovery Biology Research, Pfizer Global Research & Development, Nagoya Laboratories, Pfizer Japan Inc, 5-2 Taketoyo, Aichi 470-2393, Japan - Source
Bioorganic & medicinal chemistry letters (Print). 2008, Vol 18, Num 11, pp 3310-3314, 5 p
- ISSN
- 0960-894X
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Author keyword
- Benzimidazolone CB2 agonist Cannabinoid Metabolic stability
- Keyword (fr)
- Agoniste Analgésique Animal Biodisponibilité Dérivé du benzimidazole Hyperalgésie In vitro In vivo Pharmacocinétique Rat Relation structure activité Récepteur cannabinoïde CB2 Résistance hydrolyse Synthèse chimique Sélectivité Valine dérivé Voie orale Benzimidazolone dérivé Valinamide dérivé Valinamide(Nα-[2,3-dihydro-1-(3-hydroxy3-méthylbutyl)-2-oxobenzimidazol-1-ylcarbonyl]-3-méthyl) Mammalia Rodentia Vertebrata
- Keyword (en)
- Agonist Analgesic Animal Bioavailability Benzimidazole derivatives Hyperalgesia In vitro In vivo Pharmacokinetics Rat Structure activity relation CB2 cannabinoid receptor Hydrolysis resistance Chemical synthesis Selectivity Valine derivatives Oral administration Mammalia Rodentia Vertebrata
- Keyword (es)
- Agonista Analgésico Animal Biodisponibilidad Benzimidazol derivado Hiperalgesia In vitro In vivo Farmacocinética Rata Relación estructura actividad Receptor canabinoide CB2 Resistencia hidrólisis Síntesis química Selectividad Valina derivado Vía oral Mammalia Rodentia Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02B Neuropharmacology / 002B02B05 Analgesics
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02B Neuropharmacology / 002B02B09 Neurotransmitters. Neurotransmission. Receptors / 002B02B09G Miscellaneous
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 20411667
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmcl.2008.04.032 
https://dx.doi.org/10.1016/j.bmcl.2008.04.032
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