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A peptoid antagonist of VEGF Receptor 2 recognizes a 'hotspot' in the extracellular domain distinct from the hormone-binding site

Author
GOMIKA UDUGAMASOORIYA, D1 ; RITCHIE, Caroline1 ; BREKKEN, Rolf A2 ; KODADEK, Thomas1
[1] Departments of Internal Medicine and Molecular Biology, Division of Translational Research, University of Texas Southwestern Medical Center, Dallas, TX 75390-9185, United States
[2] Departments of Surgery and pharmacology, Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX 75390-9185, United States
Source

Bioorganic & medicinal chemistry. 2008, Vol 16, Num 12, pp 6338-6343, 6 p ; ref : 25 REF

ISSN
0968-0896
Scientific domain
Biochemistry, molecular biology, biophysics; Pharmacology drugs
Publisher
Elsevier Science, Oxford
Publication country
United Kingdom
Document type
Article
Language
English
Author keyword
Peptoid Protein-ligand binding VEGF receptor
Keyword (fr)
Affinité Antagoniste Antiangiogénique Anticancéreux Facteur angiogène Facteur croissance endothélium vasculaire Fixation ligand In vitro Inhibiteur enzyme Oligopeptide Peptide Phase solide Relation structure activité Récepteur facteur croissance Site fixation Synthèse chimique Synthèse peptidique Inhibiteur VEGFR2 Peptoïde Receptor protein-tyrosine kinase
Keyword (en)
Affinity Antagonist Antiangiogenic agent Antineoplastic agent Angiogenic factor Vascular endothelium growth factor Ligand binding In vitro Enzyme inhibitor Oligopeptides Peptides Solid phase Structure activity relation Growth factor receptor Binding site Chemical synthesis Peptide synthesis
Keyword (es)
Afinidad Antagonista Antiangiogenico Anticanceroso Factor angiógeno Factor crecimiento endotelio vascular Fijación ligando In vitro Inhibidor enzima Oligopéptido Péptido Fase sólida Relación estructura actividad Receptor factor crecimiento Sitio fijación Síntesis química Síntesis peptídica
Classification
Pascal
002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R01 General aspects

Discipline
Pharmacological treatments
Origin
Inist-CNRS
Database
PASCAL
INIST identifier
20479529

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS

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