A regiospecific synthesis of a series of 1-sulfonyl azepinoindoles as potent 5-HT6 ligands
- Author
- LIU, Kevin G1 ; LO, Jennifer R1 ; ROBICHAUD, Albert J1 ; COMERY, Thomas A2 ; GUO MING ZHANG2 ; ZHANG, Jean Y2 ; KOWAL, Dianne M2 ; SMITH, Deborah L2 ; LI DI1 ; KERNS, Edward H1 ; SCHECHTER, Lee E2
[1] Chemical & Screening Sciences, Wyeth Research, CN 8000, Princeton, NJ 08543, United States
[2] Dhcovery Neurosciences, Wyeth Research, CN 8000, Princeton, NJ 08543, United States - Source
Bioorganic & medicinal chemistry letters (Print). 2008, Vol 18, Num 14, pp 3929-3931, 3 p
- ISSN
- 0960-894X
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Author keyword
- Azepinoindole,Indolenine,5-HT6,Indole,Fischer indole synthesis
- Keyword (fr)
- In vitro Ligand Relation structure activité Récepteur sérotoninergique 5-HT6 Régiospécificité Synthèse chimique Azépino[4,5-b]indole dérivé Azépino[4,5-b]indole(3-aryl-9-arylsulfonyl-2,3,4,5-tétrahydro) Azépinoindole Synthèse indolique Fischer
- Keyword (en)
- In vitro Ligand Structure activity relation 5-HT6 serotonin receptor Regiospecificity Chemical synthesis Fischer indole synthesis
- Keyword (es)
- In vitro Ligando Relación estructura actividad Receptor serotoninérgico 5-HT6 Regiospecificidad Síntesis química
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02B Neuropharmacology / 002B02B09 Neurotransmitters. Neurotransmission. Receptors / 002B02B09C Serotoninergic system
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 20544061
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmcl.2008.06.030 
https://dx.doi.org/10.1016/j.bmcl.2008.06.030
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