Amino acid anthranilamide derivatives as a new class of glycogen phosphorylase inhibitors
- Author
- EVANS, Karen A1 ; LI, Yue H1 ; TAVARES, Francis2 ; THOMSON, Stephen A2 ; WEIEL, James E2 ; BOUCHERON, Joyce A2 ; CLANCY, Daphne C2 ; EPPERLY, Andrea H2 ; GOLDEN, Pamela L2 ; COPPO, Frank T1 ; GRAYBILL, Todd L1 ; CICHY-KNIGHT, Maria1 ; PATEL, Mehul1 ; GALE, Jennifer1 ; HU LI1 ; THRALL, Sara H1 ; TEW, David1
[1] Discovery Research, GlaxoSmithKline Pharmaceuticals, 1250 South Collegeville Road, PO Box 5089, Collegeville, PA 19426-0989, United States
[2] Metabolic and Viral Diseases Center of Excellence for Drug Discovery, GlaxoSmithKline Pharmaceuticals, Five Moore Drive, PO Box 13398, Research Triangle Park, NC 27709-3398, United States - Source
Bioorganic & medicinal chemistry letters (Print). 2008, Vol 18, Num 14, pp 4068-4071, 4 p
- ISSN
- 0960-894X
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Author keyword
- Human liver glycogen phosphorylase,Glycogen phosphorylase inhibitors,Solid-phase synthesis
- Keyword (fr)
- Aminoacide Animal Chlore Composé organique Diabète de type 2 Foie Homme Hypoglycémiant In vitro In vivo Inhibiteur enzyme Pharmacocinétique Phase solide Phosphorylase Rat Relation structure activité Stabilité Synthèse chimique Urées Voie intraveineuse Voie orale Anthranilamide dérivé Aspartique acide(N-[3-(3-[2,6-dichlorophényl]uréido)-2-naphtoyl]) Endocrinopathie Enzyme Glycosyltransferases Hexosyltransferases Maladie métabolique Mammalia Rodentia Transferases Vertebrata
- Keyword (en)
- Aminoacid Animal Chlorine Organic compounds Type 2 diabetes Liver Human Hypoglycemic agent In vitro In vivo Enzyme inhibitor Pharmacokinetics Solid phase Phosphorylase Rat Structure activity relation Stability Chemical synthesis Ureas Intravenous administration Oral administration Endocrinopathy Enzyme Glycosyltransferases Hexosyltransferases Metabolic diseases Mammalia Rodentia Transferases Vertebrata
- Keyword (es)
- Aminoácido Animal Cloro Compuesto orgánico Diabetes de tipo 2 Hígado Hombre Hipoglicemiante In vitro In vivo Inhibidor enzima Farmacocinética Fase sólida Phosphorylase Rata Relación estructura actividad Estabilidad Síntesis química Ureas Vía intravenosa Vía oral Endocrinopatía Enzima Glycosyltransferases Hexosyltransferases Metabolismo patología Mammalia Rodentia Transferases Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02N General and cellular metabolism. Vitamins
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 20544094
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmcl.2008.05.102 
https://dx.doi.org/10.1016/j.bmcl.2008.05.102
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