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A phase I safety, pharmacological, and biological study of the farnesyl protein transferase inhibitor, lonafarnib (SCH 663366), in combination with cisplatin and gemcitabine in patients with advanced solid tumors

Author
CHOW, Laura Q. M1 ; ECKHARDT, S. Gail1 ; O'BRYANT, Cindy L1 ; SCHULTZ, Mary Kay1 ; MORROW, Mark1 ; GROLNIC, Stacy1 ; BASCHE, Michele1 ; GORE, Lia2
[1] University of Colorado Cancer Center, Aurora, CO, United States
[2] The Children's Hospital, Denver, CO, United States
Source

Cancer chemotherapy and pharmacology. 2008, Vol 62, Num 4, pp 631-646, 16 p ; ref : 46 ref

CODEN
CCPHDZ
ISSN
0344-5704
Scientific domain
Medical oncology; Pharmacology drugs
Publisher
Springer, Berlin
Publication country
Germany
Document type
Article
Language
English
Author keyword
Cisplatin Gemcitabine, Famesyltransferase, Phase I Lonafarnib Pharmacokinetics SCH66336
Keyword (fr)
Anticancéreux Association médicamenteuse Cisplatine Farnesyl-diphosphate farnesyltransferase Gemcitabine Homme Inhibiteur protéique Lonafarnib Pharmacocinétique Stade avancé Toxicité Tumeur solide Agent alkylant Antimétabolite Cancer Dérivé de la pyrimidine Enzyme Fluor Composé organique Platine II Complexe Pyrimidine nucléoside Transferases Tumeur maligne
Keyword (en)
Antineoplastic agent Drug combination Cisplatin Farnesyl-diphosphate farnesyltransferase Gemcitabine Human Protein inhibitor Lonafarnib Pharmacokinetics Advanced stage Toxicity Solid tumor Alkylating agent Antimetabolic Cancer Pyrimidine derivatives Enzyme Fluorine Organic compounds Platinum II Complexes Pyrimidine nucleoside Transferases Malignant tumor
Keyword (es)
Anticanceroso Asociación medicamentosa Cisplatino Farnesyl-diphosphate farnesyltransferase Gemcitabina Hombre Inhibidor proteico Lonafarnib Farmacocinética Estadio avanzado Toxicidad Tumor sólido Agente alquilante Antimetabólito Cáncer Pirimidina derivado Enzima Fluor Compuesto orgánico Platino II Complejo Pirimidina nucleósido Transferases Tumor maligno
Classification
Pascal
002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents

Pascal
002 Biological and medical sciences / 002B Medical sciences / 002B04 Tumors / 002B04C Multiple tumors. Solid tumors. Tumors in childhood (general aspects)

Discipline
Pharmacological treatments Tumours
Origin
Inist-CNRS
Database
PASCAL
INIST identifier
20551447

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS

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