Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease
- Author
- BARRETT, Jeffrey C1 ; HANSOUL, Sarah2 ; BITTON, Alain13 ; DASSOPOULOS, Themistocles9 ; WU DATTA, Lisa9 ; GREEN, Todd8 ; GRIFFITHS, Anne M14 ; KISTNER, Emily O15 ; MURTHA, Michael T4 ; REGUEIRO, Miguel D5 ; ROTTER, Jerome I12 ; SCHUMM, L. Philip15 ; NICOLAE, Dan L3 ; STEINHART, A. Hillary11 ; TARGAN, Stephan R12 ; XAVIER, Ramnik J16 ; LIBIOULLE, Cécile2 ; SANDOR, Cynthia2 ; LATHROP, Mark17 ; BELAICHE, Jacques18 ; DEWIT, Olivier19 ; GUT, Ivo17 ; HEATH, Simon17 ; CHO, Judy H4 ; LAUKENS, Debby20 ; MNI, Myriam2 ; RUTGEERTS, Paul21 ; VAN GOSSUM, André22 ; ZELENIKA, Diana17 ; FRANCHIMONT, Denis22 ; HUGOT, Jean-Pierre23 ; DE VOS, Martine20 ; VERMEIRE, Severine21 ; LOUIS, Edouard18 ; DUERR, Richard H5 6 ; CARDON, Lon R1 ; ANDERSON, Carl A1 ; DRUMMOND, Hazel24 ; NIMMO, Elaine24 ; AHMAD, Tariq25 ; PRESCOTT, Natalie J; ONNIE, Clive M; FISHER, Sheila A; MARCHINI, Jonathan; GHORI, Jilur; RIOUX, John D7 8 ; BUMPSTEAD, Suzannah; GWILLIAM, Rhian; TREMELLING, Mark; DELOUKAS, Panos; MANSFIELD, John; JEWELL, Derek; SATSANGI, Jack24 ; MATHEW, Christopher G; PARKES, Miles; GEORGES, Michel2 ; BRANT, Steven R10 9 ; SILVERBERG, Mark S11 ; TAYLOR, Kent D12 ; BARMADA, M. Michael6
[1] Bioinformatics and Statistical Genetics, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford 0X3 7BN, United Kingdom
[2] Unit of Animal Genomics, GIGA-R and Faculty of Veterinary Medicine, University of Liège, Belgium
[3] University of Chicago, Department of Medicine, 5801 South Ellis, Chicago, Illinois 60637, United States
[4] Yale University, Departments of Medicine and Genetics, Division of Gastroenterology, Inflammatory Bowel Disease (IBD) Center, 300 Cedar Street, New Haven, Connecticut 06519, United States
[5] University of Pittsburgh, School of Medicine, Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh Medical Center (UPMC) Presbyterian, 200 Lothrop Street, Pittsburgh, Pennsylvania 15213, United States
[6] University of Pittsburgh, Graduate School of Public Health, Department of Human Genetics, 130 Desoto Street, Pittsburgh, Pennsylvania 15261, United States
[7] Université de Montréal and the Montreal Heart Institute, Research Center, 5000 rue Belanger, Montreal, Quebec HIT 1C8, Canada
[8] The Broad Institute of Massachusetts Institute of Technology and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, United States
[9] Johns Hopkins University, Department of Medicine, Harvey M. and Lyn P. Meyerhoff Inflammatory Bowel Disease Center, 1503 East Jefferson Street, Baltimore, Maryland 21231, United States
[10] Johns Hopkins University, Bloomberg School of Public Health, Department of Epidemiology, 615 E. Wolfe Street, Baltimore, Maryland 21205, United States
[11] Mount Sinai Hospital IBD Centre, University of Toronto, 441-600 University Avenue, Toronto, Ontario M5G 1X5, Canada
[12] Medical Genetics Institute and Inflammatory Bowel Disease (IBD) Center, Cedars-Sinai Medical Center, 8700 W. Beverly Blvd, Los Angeles, California 90048, United States
[13] Department of Medicine, Royal Victoria Hospital, McGill University, Montreal, Quebec, H3A 1A1, Canada
[14] The Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
[15] University of Chicago, Department of Health Studies, 5841 S. Maryland Avenue, Chicago, Illinois 60637, United States
[16] Gastrointestinal Unit and Center for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street, Boston, Massachusetts 02114, United States
[17] Centre National de Génotypage, Evry, France
[18] Unit of Hepatology and Gastroenterology, Department of Clinical Sciences, GIGA-R, Faculty of Medicine and CHU de Liège, University of Liège, Belgium
[19] Department of Gastroenterology, Clinique universitaire St Luc, UCL, Brussels, Belgium
[20] Department of Hepatology and Gastroenterology, Ghent University Hospital, Belgium
[21] Department of Gastroenterology, University Hospital Leuven, Belgium
[22] Department of Gastroenterology, Erasmus Hospital, Free University of Brussels, Belgium
[23] INSERM; Université Paris Diderot; Assistance Publique Hôpitaux de Paris; Hopital Robert Debré, Paris, France
[24] Gastrointestinal Unit, Division of Medical Sciences, School of Molecular and Clinical Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, United Kingdom
[25] Peninsula Medical School, Barrack Road, Exeter, EX2 5DW, United Kingdom
Wellcome Trust Case Control Consortium - Source
Nature genetics. 2008, Vol 40, Num 8, pp 955-962, 8 p ; ref : 50 ref
- Publisher
- Nature Publishing Group, London
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Keyword (fr)
- Entérite de Crohn Locus Association génétique Echelle du génome Maladie inflammatoire Pathologie de l'appareil digestif Pathologie de l'intestin
- Keyword (en)
- Crohn disease Locus Inflammatory disease Digestive diseases Intestinal disease
- Keyword (es)
- Enteritis Crohn Locus Enfermedad inflamatoria Aparato digestivo patología Intestino patología
- Classification
- Pascal
- 002 Biological and medical sciences / 002A Fundamental and applied biological sciences. Psychology / 002A07 Genetics of eukaryotes. Biological and molecular evolution
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B13 Gastroenterology. Liver. Pancreas. Abdomen / 002B13B Stomach. Duodenum. Small intestine. Colon. Rectum. Anus / 002B13B03 Other diseases. Semiology
- Discipline
- Eukaryotes genetics. Biological and molecular evolution Gastroenterology. Liver. Pancreas. Abdomen
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 20551865
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1038/ng.175 
https://dx.doi.org/10.1038/ng.175
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arXiv access
