The Effect of CYP2C19 Polymorphism on the Pharmacokinetics and Pharmacodynamics of Clopidogrel : A Possible Mechanism for Clopidogrel Resistance
- Author
- KIM, K. A1 ; PARK, P. W2 ; HONG, S. J3 ; PARK, J-Y1
[1] Department of Clinical Pharmacology and Toxicology, Anam Hospital, Korea University College of Medicine, Seoul, Korea, Republic of
[2] Department of Laboratory Medicine, Gil Medical Center and Gachon Medical School, Incheon, Korea, Republic of
[3] Department of Cardiology, Anam Hospital, Korea University College of Medicine, Seoul, Korea, Republic of - Source
Clinical pharmacology and therapeutics. 2008, Vol 84, Num 2, pp 236-242, 7 p ; ref : 42 ref
- CODEN
- CLPTAT
- ISSN
- 0009-9236
- Scientific domain
- Pharmacology drugs
- Publisher
- Nature Publishing, New York, NY
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Antithrombotique Clopidogrel Cytochrome P450 Génotype Homme Inhibiteur thromboagrégation Isozyme Mécanisme action Polymorphisme Relation pharmacocinétique pharmacodynamie Résistance Variabilité génétique Dérivé de la thiénopyridine Enzyme
- Keyword (en)
- Antithrombotic agent Clopidogrel Cytochrome P450 Genotype Human Antiplatelet agent Isozyme Mechanism of action Polymorphism Pharmacokinetic pharmacodynamic relationship Resistance Genetic variability Thienopyridine derivative Enzyme
- Keyword (es)
- antitrombōtico Clopidogrel Citocromo P450 Genotipo Hombre Inhibidor tromboagregación Isozima Mecanismo acción Polimorfismo Relación farmacocinética farmacodinamia Resistencia Variabilidad genética Tienopiridina derivado Enzima
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments
- Discipline
- General pharmacology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 20566845
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1038/clpt.2008.20 
https://dx.doi.org/10.1038/clpt.2008.20
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