A one-mutation mathematical model can explain the age incidence of acute myeloid leukemia with mutated nucleophosmin (NPM1)

Author

LISO, Arcangelo¹ ; CASTIGLIONE, Filippo² ; MARTELLI, Massimo F⁹ ; SCHAICH, Markus⁶ ; KRAUTER, Jürgen¹⁰ ; GANSER, Arnold¹⁰ ; MARTELLI, Maria P⁹ ; BOLLI, Niccolo⁹ ; LÖWENBERG, Bob⁸ ; HAFERLACH, Torsten⁷ ; EHNINGER, Gerhard⁶ ; MANDELLI, Franco¹¹ ; CAPPUCCIO, Antonio² ; DÖHNER, Hartmut⁴ ; MICHOR, Franziska¹² ; FALINI, Brunangelo⁹ ; STRACCI, Fabrizio³ ; SCHLENK, Richard F⁴ ; AMADORI, Sergio⁵ ; THIEDE, Christian⁶ ; SCHNITTGER, Susanne⁷ ; VALK, Peter J. M⁸ ; DÖHNER, Konstanze⁴
[1] Institute of Hematology, University of Foggia, Foggia, Italy
[2] Istituto Applicazioni del Calcolo M. Picone, Consiglio Nazionale delle Ricerche (CNR), Rome, Italy
[3] Dept. Surg. Med. Spec. and Public Health, University of Perugia, Italy
[4] Department of Internal Medicine III, University of Ulm, Ulm, Germany
[5] Institute of Hematology, University of Tor Vergata, Rome, Italy
[6] Laboratory for Molecular Diagnostics, University Hospital Carl Gustav Carus, Dresden, Germany
[7] MLL-Munich Leukemia Laboratory, Munich, Germany
[8] Department of Hematology, Erasmus University Medical Center, Rotterdam, Netherlands
[9] Institute of Hematology, University of Perugia, Perugia, Italy
[10] Department of Hematology, Hemostasis and Oncology, Hannover Medical School, Hannover, Germany
[11] Institute of Hematology, University La Sapienza, Rome, Italy
[12] Computational Biology Center, Memorial Sloan Kettering Cancer Center, New York, NY, United States

Source

Haematologica (Roma). 2008, Vol 93, Num 8, pp 1219-1226, 8 p ; ref : 47 ref

ISSN

0390-6078

Scientific domain

Hematology

Publisher

Haematologica, Pavia

Publication country

Italy

Document type

Article

Language

English

Author keyword

acute myeloid leukemia mutation nucleophosmin

Keyword (fr)

Age Epidémiologie Génétique Hématologie Incidence Leucémie aiguë myéloblastique Modèle mathématique Mutation Gène NPM1 Nucléophosmine Cancer Hémopathie maligne

Keyword (en)

Age Epidemiology Genetics Hematology Incidence Acute myelogenous leukemia Mathematical model Mutation NPM1 gene Nucleophosmin Cancer Malignant hemopathy

Keyword (es)

Edad Epidemiología Genética Hematología Incidencia Leucemia aguda mieloblástica Modelo matemático Mutación Cáncer Hemopatía maligna

Classification

Pascal

002 Biological and medical sciences / 002B Medical sciences / 002B19 Hematologic and hematopoietic diseases / 002B19B Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis

Discipline

Blood diseases

Origin

Inist-CNRS

Database

PASCAL

INIST identifier

20568968

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS