Synthesis of hydantoin analogues of (25,3R,45)-4-hydroxyisoleucine with insulinotropic properties
- Author
- SERGENT, Didier1 ; QIAN WANG1 ; SASAKI, N. Andre1 ; OUAZZANI, Jamal1
[1] Institut de Chimie des Substances Naturelles, CNRS, UPR 2301, Avenue de la Terrasse, 91198 Gif-sur-Yvette, France - Source
Bioorganic & medicinal chemistry letters (Print). 2008, Vol 18, Num 15, pp 4332-4335, 4 p
- ISSN
- 0960-894X
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Author keyword
- Type-2 diabetes;Fenugreek;4-Hydroxyisoleucine;Hydantoin;Insulin secretion
- Keyword (fr)
- Activité biologique Animal Diabète de type 2 Hormone pancréatique Hormone protéine Hydantoïnes Hypoglycémiant Ilot Langerhans In vitro Insuline Rat Solution acide Stabilité chimique Stéréoisomère Synthèse chimique Sécrétion Hydantoïne(5-[2-hydroxy-1-méthylpropyl]) Imidazolidine dérivé Mammalia Rodentia Vertebrata
- Keyword (en)
- Biological activity Animal Type 2 diabetes Pancreatic hormone Protein hormone Hydantoins Hypoglycemic agent Langerhans islet In vitro Insulin Rat Acidic solution Chemical stability Stereoisomer Chemical synthesis Secretion Mammalia Rodentia Vertebrata
- Keyword (es)
- Actividad biológica Animal Diabetes de tipo 2 Hormona pancreática Hormona proteina Hidantoínas Hipoglicemiante Isla Langerhans In vitro Insulina Rata Solución ácida Estabilidad química Estereoisómero Síntesis química Secreción Mammalia Rodentia Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02N General and cellular metabolism. Vitamins
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 20581873
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmcl.2008.06.081 
https://dx.doi.org/10.1016/j.bmcl.2008.06.081
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