Biphenyl amide p38 kinase inhibitors 3: Improvement of cellular and in vivo activity
- Autor
- ANGELL, Richard1 ; ASTON, Nicola M1 ; PATEL, Shila1 ; SMEE, Penny A1 ; SMITH, Kathryn J1 ; SOMERS, Don O1 ; WALKER, Ann L1 ; BAMBOROUGH, Paul1 ; BUCKTON, Jacky B1 ; COCKERILL, Stuart1 ; DEBOECK, Suzanne J1 ; EDWARDS, Chris D1 ; HOLMES, Duncan S1 ; JONES, Katherine L1 ; LAINE, Dramane I1
[1] GlaxoSmithKline R&D, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, United Kingdom - Fuente
Bioorganic & medicinal chemistry letters (Print). 2008, Vol 18, Num 15, pp 4428-4432, 5 p
- ISSN
- 0960-894X
- Campo Científico
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Editor
- Elsevier, Oxford
- País de la publicación
- United Kingdom
- Tipo de documento
- Article
- Idioma
- English
- Palabra clave de autor
- p38 Kinase;p38 Alpha;p38;CSBP;MAP kinase;Inhibitors;Biphenyl amide;BPA;Biphenyl amides;BPAs;Protein kinase X-ray structure;Binding mode;Structure-based drug design;Kinase selectivity;Structure-activity relationships;PG-PS model;CIA model
- Palabra clave (fr)
- Animal Carboxamide Diffraction RX Dérivé du biphényle Dérivé du cyclopropane In vivo Inhibiteur Mitogen-activated protein kinase Mode liaison Modèle moléculaire Modélisation Pharmacocinétique Rat Relation structure activité Structure cristalline Structure moléculaire Voie intraveineuse Voie orale Biphényle-3,4p-dicarboxamide(N,N-bis[cyclopropylméthyl]-6-méthyl) Enzyme Mammalia Rodentia Transferases Vertebrata
- Palabra clave (in)
- Animal Carboxamide X ray diffraction Biphenyl derivatives Cyclopropane derivatives In vivo Inhibitor Mitogen-activated protein kinase Binding mode Molecular model Modeling Pharmacokinetics Rat Structure activity relation Crystalline structure Molecular structure Intravenous administration Oral administration Enzyme Mammalia Rodentia Transferases Vertebrata
- Palabra clave (es)
- Animal Carboxamida Difracción RX Bifenilo derivado Ciclopropano derivado In vivo Inhibidor Mitogen-activated protein kinase Modo de enlace Modelo molecular Modelización Farmacocinética Rata Relación estructura actividad Estructura cristalina Estructura molecular Vía intravenosa Vía oral Enzima Mammalia Rodentia Transferases Vertebrata
- Clasificación
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02W Miscellaneous
- Disciplina
- General pharmacology
- Procedencia
- Inist-CNRS
- Base de datos
- PASCAL
- Identificador INIST
- 20581897
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmcl.2008.06.048 
https://dx.doi.org/10.1016/j.bmcl.2008.06.048
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