Structure-based redesign of the dimerization interface reduces the toxicity of zinc-finger nucleases
- Author
- SZCZEPEK, Michal1 ; BRONDANI, Vincent2 ; BÜCHEL, Janine1 ; SERRANO, Luis3 ; SEGAL, David J2 ; CATHOMEN, Toni1
[1] Charité Medical School, Institute of Virology (CBF), 12203 Berlin, Germany
[2] University of California Davis, Genome Center and Department of Pharmacology, Davis, California 95616, United States
[3] Centre de Regulacio Genomica, CRG-EMBL Systems Biology Unit, 08003 Barcelona, Spain - Source
Nature biotechnology (Print). 2007, Vol 25, Num 7, pp 786-793, 8 p ; ref : 42 ref
- CODEN
- NABIF9
- ISSN
- 1087-0156
- Scientific domain
- Biotechnology
- Publisher
- Nature Publishing Group, New York, NY
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Ciblage Clivage Cytotoxicité Dimérisation Gène Génie protéique Modélisation Mutagenèse Recombinaison homologue Restriction endonuclease Spécificité Toxicité Zinc-finger nuclease Enzyme
- Keyword (en)
- Targeting Cleavage Cytotoxicity Dimerization Gene Protein engineering Modeling Mutagenesis Homologous recombination Restriction endonuclease Specificity Toxicity Zinc-finger nuclease Enzyme
- Keyword (es)
- Blancado Clivaje Citotoxicidad Dimerización Gen Ingenieria de proteinas Modelización Mutagénesis Recombinación homólogo Restriction endonuclease Especificidad Toxicidad Enzima
- Classification
- Pascal
- 002 Biological and medical sciences / 002A Fundamental and applied biological sciences. Psychology / 002A31 Biotechnology / 002A31C Methods. Procedures. Technologies / 002A31C04 Protein engineering
- Discipline
- Biotechnology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 20634923
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1038/nbt1317 
https://dx.doi.org/10.1038/nbt1317
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