Discovery and stereoselective synthesis of the novel isochroman neurokinin-1 receptor antagonist 'CJ-17,493'
- Autor
- SHISHIDO, Yuji1 ; WAKABAYASHI, Hiroaki1 ; FUJIWARA, Yoshiko1 ; SAKAKIBARA, Ayano1 ; SUGA, Osamu1 ; KUSANO, Rinko1 ; UEDA, Satoko1 ; KANAI, Yoshihito1 ; TSUCHIYA, Megumi1 ; SATAKE, Kunio1 ; KOIKE, Hiroki1 ; UENO, Naomi1 ; NUKUI, Seiji; YAMAGISHI, Tatsuya1 ; MURATA, Yoshinori1 ; NAGANEO, Fumiharu1 ; MIZUTANI, Mayumi1 ; SHIMADA, Kaoru1
[1] Pfizer Global Research & Development, Nagoya Laboratories, 5-2 Taketoyo, Aichi 470-2394, Japan - Fuente
Bioorganic & medicinal chemistry. 2008, Vol 16, Num 15, pp 7193-7205, 13 p ; ref : 15 ref
- ISSN
- 0968-0896
- Campo Científico
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Editor
- Elsevier Science, Oxford
- País de la publicación
- United Kingdom
- Tipo de documento
- Article
- Idioma
- English
- Palabra clave de autor
- Antagonist CJ-17,493 CP-122,721 CYP2D6 Kinetic resolution Lipase PS Neurokinin-1
- Palabra clave (fr)
- Activité biologique Animal Antagoniste Antiémétique Cytochrome P450 Drug-metabolizing enzyme Dédoublement optique Enantiomère Furet In vitro In vivo Isozyme Pharmacocinétique Rat Réaction enzymatique Récepteur tachykinine NK1 Stéréosélectivité Synthèse chimique Séparation Triacylglycerol lipase Unspecific monooxygenase Voie intracérébrale Voie intraveineuse Voie orale 2-Benzopyrane dérivé Cytochrome CYP2D6 Isochromane dérivé Lignée IM9 Carboxylic ester hydrolases Carnivora Enzyme Esterases Fissipedia Hydrolases Mammalia Oxidoreductases Rodentia Vertebrata
- Palabra clave (in)
- Biological activity Animal Antagonist Antiemetic Cytochrome P450 Drug-metabolizing enzyme Optical resolution Enantiomer Ferret In vitro In vivo Isozyme Pharmacokinetics Rat Enzymatic reaction NK1 Tachykinin receptor Stereoselectivity Chemical synthesis Separation Triacylglycerol lipase Unspecific monooxygenase Intracerebral administration Intravenous administration Oral administration Carboxylic ester hydrolases Carnivora Enzyme Esterases Fissipedia Hydrolases Mammalia Oxidoreductases Rodentia Vertebrata
- Palabra clave (es)
- Actividad biológica Animal Antagonista Antiemético Citocromo P450 Drug-metabolizing enzyme Desdoblamiento óptico Enantiómero Hurón In vitro In vivo Isozima Farmacocinética Rata Reacción enzimática Receptor taquikinina NK1 Estereoselectividad Síntesis química Separación Triacylglycerol lipase Unspecific monooxygenase Vía intracerebral Vía intravenosa Vía oral Carboxylic ester hydrolases Carnivora Enzima Esterases Fissipedia Hydrolases Mammalia Oxidoreductases Rodentia Vertebrata
- Clasificación
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02B Neuropharmacology / 002B02B09 Neurotransmitters. Neurotransmission. Receptors / 002B02B09F Peptidergic system (neuropeptide, opioid peptide, opiates...). Adenosinergic and purinergic systems
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02H Digestive system
- Disciplina
- Pharmacological treatments
- Procedencia
- Inist-CNRS
- Base de datos
- PASCAL
- Identificador INIST
- 20635351
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmc.2008.06.047 
https://dx.doi.org/10.1016/j.bmc.2008.06.047
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