Synthesis of new sulfonyl pyrrolidine derivatives as matrix metalloproteinase inhibitors
- Author
- CHENG, Xian-Chao1 ; QIANG WANG1 ; HAO FANG1 ; WEI TANG2 ; XU, Wen-Fang1
[1] Institute of Medicinal Chemistry, School of Pharmaceutical Sciences, Shandong University, No.44 Wenhuaxi Road, Jinan 250012, China
[2] Hepato-Biliary-Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine, The University of Tokyo, 713-8655, Japan - Source
Bioorganic & medicinal chemistry. 2008, Vol 16, Num 17, pp 7932-7938, 7 p ; ref : 16 ref
- ISSN
- 0968-0896
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier Science, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Author keyword
- IC50 MMP-2 inhibitors Pyrrolidine derivatives Synthesis
- Keyword (fr)
- Acide hydroxamique Anticancéreux Complexe enzyme inhibiteur Gelatinase A Hétérocycle azote In vitro Inhibiteur enzyme Mode liaison Modèle moléculaire Modélisation Relation structure activité Sulfonamide Sulfonate Synthèse chimique Inhibiteur metalloendopeptidases Pyrrolidine-2-carbohydroxamique acide(1-benzènesulfonyl-4-hydroxy) Pyrrolidine-2-carbohydroxamique acide(4-hydroxy-1-p-tosyl) Pyrrolidine-2-carboxylique acide(1-benzènesulfonyl-4-p-tosyloxy) ester méthyle Pyrrolidine-2-carboxylique acide(1-p-tosyl-4-p-tosyloxy) ester méthyle Enzyme Hydrolases Metalloendopeptidases Peptidases
- Keyword (en)
- Hydroxamic acid Antineoplastic agent Inhibitor enzyme complex Gelatinase A Nitrogen heterocycle In vitro Enzyme inhibitor Binding mode Molecular model Modeling Structure activity relation Sulfonamide Sulfonate Chemical synthesis Enzyme Hydrolases Metalloendopeptidases Peptidases
- Keyword (es)
- Acido hidroxámico Anticanceroso Complejo enzima inhibidor Gelatinase A Heterociclo nitrógeno In vitro Inhibidor enzima Modo de enlace Modelo molecular Modelización Relación estructura actividad Sulfonamida Sulfonato Síntesis química Enzima Hydrolases Metalloendopeptidases Peptidases
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R01 General aspects
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 20667191
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmc.2008.07.073 
https://dx.doi.org/10.1016/j.bmc.2008.07.073
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