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A pharmacokinetic and pharmacogenetic study of efavirenz in children : dosing guidelines can result in subtherapeutic concentrations

Author
TER HEINE, Rob1 ; SCHERPBIER, Henriette J2 ; CROMMENTUYN, Kristel M. L1 ; BEKKER, Vincent2 ; BEIJNEN, Jos H1 ; KUIJPERS, Taco W2 ; HUITEMA, Alwin D. R1
[1] Department of Pharmacy εt Pharmacology, Slotervaart Hospital, Amsterdam, Netherlands
[2] Department of Pediatrics, Emma Children's Hospital, Amsterdam, Netherlands
Source

Antiviral therapy (London). 2008, Vol 13, Num 6, pp 779-787, 9 p ; ref : 30 ref

ISSN
1359-6535
Scientific domain
Microbiology, infectious diseases; Pharmacology drugs; Virology
Publisher
International Medical Press, London
Publication country
United Kingdom
Document type
Article
Language
English
Keyword (fr)
Adaptation posologie Antirétroviral Antiviral Concentration Cytochrome P450 Efavirenz Enfant Génotype Isozyme Pharmacocinétique de la population Pharmacogénétique Recommandation Cytochrome CYP2B6 Composé acétylénique Composé non nucléoside Dérivé de la benzoxazine Enzyme Génétique Homme Inhibiteur allostérique Inhibiteur enzyme Inhibiteur reverse transcriptase Nucleotidyltransferases RNA-directed DNA polymerase Transferases
Keyword (en)
Dosage adjustment Antiretroviral agent Antiviral Concentration Cytochrome P450 Efavirenz Child Genotype Isozyme Population pharmacokinetics Pharmacogenetics Recommendation Acetylenic compound Non nucleoside compound Benzoxazine derivatives Enzyme Genetics Human Allosteric inhibitor Enzyme inhibitor Reverse transcriptase inhibitor Nucleotidyltransferases RNA-directed DNA polymerase Transferases
Keyword (es)
Adaptación posología Antiretroviral Antiviral Concentración Citocromo P450 Efavirenz Niño Genotipo Isozima Farmacocinética población Farmacogenética Recomendación Compuesto acetilénico Compuesto no nucleósido Benzoxazina derivado Enzima Genética Hombre Inhibidor alostérico Inhibidor enzima Inhibitor reverse transcriptase Nucleotidyltransferases RNA-directed DNA polymerase Transferases
Classification
Pascal
002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02S Antibiotics. Antiinfectious agents. Antiparasitic agents / 002B02S05 Antiviral agents

Discipline
Pharmacological treatments
Origin
Inist-CNRS
Database
PASCAL
INIST identifier
20674515

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS

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