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Enantiomeric Propanolamines as selective N-Methyl-D-aspartate 2B Receptor Antagonists

Author
TAHIROVIC, Yesim A1 ; GEBALLE, Matthew1 ; HONGJIE YUAN3 ; WILSON, Lawrence J1 ; KOTLOSKI, Robert4 ; MCNAMARA, James O4 ; DINGLEDINE, Raymond3 ; LIOTTA, Dennis C1 ; TRAYNELIS, Stephen F3 ; SNYDER, James P1 ; GRUSZECKA-KOWALIK, Ewa2 ; MYERS, Scott J3 ; LYUBOSLAVSKY, Polina3 ; LE, Phuong3 ; FRENCH, Adam3 ; IRIER, Hasan3 ; CHOI, Woo-Baeg2 ; EASTERLING, Keith3
[1] Department of Chemistry, Emory University, Atlanta, Georgia, United States
[2] FOB Synthesis, Inc., Emtech Bio (Emory University and Georgia Tech), Atlanta, Georgia, United States
[3] Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia, United States
[4] Department of Neurobiology, Duke University, Durham, North Carolina, United States
Source

Journal of medicinal chemistry (Print). 2008, Vol 51, Num 18, pp 5506-5521, 16 p ; ref : 79 ref

CODEN
JMCMAR
ISSN
0022-2623
Scientific domain
Pharmacology drugs
Publisher
American Chemical Society, Washington, DC
Publication country
United States
Document type
Article
Language
English
Keyword (fr)
Affinité Aminoalcool Animal Antagoniste Anticonvulsivant Dérivé du benzène Enantiomère Hydroxyéther In vitro In vivo Locomotion Modèle moléculaire Modèle électrostatique Modélisation Neuroprotecteur Rat Relation structure activité Récepteur NMDA Récepteur glutamate Souris Sulfonamide Sélectivité Voie intrapéritonéale MéthanesulfonamideN-[4-(3-[(3,4-dichlorophénéthyl)amino]-2-hydroxypropoxy)phényl] Propanolamine dérivé Sous-unité NMDA R2B Chlore Composé organique Mammalia Rodentia Vertebrata
Keyword (en)
Affinity Aminoalcohol Animal Antagonist Anticonvulsant Benzene derivatives Enantiomer Hydroxyether In vitro In vivo Locomotion Molecular model Electrostatic model Modeling Neuroprotective agent Rat Structure activity relation NMDA receptor Glutamate receptor Mouse Sulfonamide Selectivity Intraperitoneal administration Chlorine Organic compounds Mammalia Rodentia Vertebrata
Keyword (es)
Afinidad Aminoalcohol Animal Antagonista Anticonvulsivante Benceno derivado Enantiómero Hidroxieter In vitro In vivo Locomoción Modelo molecular Modelo electrostático Modelización Neuroprotector Rata Relación estructura actividad Receptor NMDA Receptor glutámato Ratón Sulfonamida Selectividad Vía intraperitoneal Cloro Compuesto orgánico Mammalia Rodentia Vertebrata
Classification
Pascal
002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02B Neuropharmacology / 002B02B06 Anticonvulsants. Antiepileptics. Antiparkinson agents

Pascal
002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02B Neuropharmacology / 002B02B09 Neurotransmitters. Neurotransmission. Receptors / 002B02B09E Glutamatergic system (aspartate and other excitatory aminoacids)

Pascal
002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02B Neuropharmacology / 002B02B10 Neuroprotective agent

Discipline
Pharmacological treatments Psychopathology. Psychiatry. Clinical psychology
Origin
Inist-CNRS
Database
PASCAL
INIST identifier
20687105

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS

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