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Aminoacyl-Anthraquinone Conjugates as Telomerase Inhibitors : Synthesis, Biophysical and Biological Evaluation

Author
ZAGOTTO, Giuseppe1 ; SISSI, Claudia1 ; LUCATELLO, Lorena1 ; PIVETTA, Claudia1 ; CADAMURO, Sergio A1 ; FOX, Keith R2 ; NEIDLE, Stephen3 ; PALUMBO, Manlio1
[1] Department of Pharmaceutical Sciences, University of Padova, Via Marzolo 5, 35131 Padova, Italy
[2] School of Biological Sciences, University of Southampton, Bassett Crescent East, Southampton SO 16 7PX, United Kingdom
[3] CRUK Biomolecular Structure Group, The School of Pharmacy, University of London, London WC1N 1AX, United Kingdom
Source

Journal of medicinal chemistry (Print). 2008, Vol 51, Num 18, pp 5566-5574, 9 p ; ref : 22 ref

CODEN
JMCMAR
ISSN
0022-2623
Scientific domain
Pharmacology drugs
Publisher
American Chemical Society, Washington, DC
Publication country
United States
Document type
Article
Language
English
Keyword (fr)
Aminoamide Anticancéreux Cellule tumorale Col utérus Composé benzénique condensé Composé conjugué Composé tricyclique Cytotoxicité Dérivé de l'anthraquinone Embryon Homme In vitro Inhibiteur de la télomérase Inhibiteur enzyme Lignée HeLa Lignée cellulaire Nucleotidyltransferases Quinone Rein Relation structure activité Synthèse chimique Telomerase α-Aminoacide Lignée 293T Enzyme Transferases
Keyword (en)
Aminoamide Antineoplastic agent Tumor cell Uterine cervix Condensed benzenic compound Conjugated compound Tricyclic compound Cytotoxicity Anthraquinone derivatives Embryo Human In vitro Telomerase inhibitor Enzyme inhibitor Hela cell line Cell line Nucleotidyltransferases Quinone Kidney Structure activity relation Chemical synthesis Telomerase α-Aminoacid Enzyme Transferases
Keyword (es)
Aminoamida Anticanceroso Célula tumoral Cuello útero Compuesto bencénico condensado Compuesto conjugado Compuesto tricíclico Citotoxicidad Antraquinona derivado Embrión Hombre In vitro Inhibidor telomerase Inhibidor enzima Célula HeLa Línea celular Nucleotidyltransferases Quinona Riñón Relación estructura actividad Síntesis química Telomerase α-Aminoácido Enzima Transferases
Classification
Pascal
002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R01 General aspects

Discipline
Pharmacological treatments
Origin
Inist-CNRS
Database
PASCAL
INIST identifier
20687110

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS

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