Aminoacyl-Anthraquinone Conjugates as Telomerase Inhibitors : Synthesis, Biophysical and Biological Evaluation
- Author
- ZAGOTTO, Giuseppe1 ; SISSI, Claudia1 ; LUCATELLO, Lorena1 ; PIVETTA, Claudia1 ; CADAMURO, Sergio A1 ; FOX, Keith R2 ; NEIDLE, Stephen3 ; PALUMBO, Manlio1
[1] Department of Pharmaceutical Sciences, University of Padova, Via Marzolo 5, 35131 Padova, Italy
[2] School of Biological Sciences, University of Southampton, Bassett Crescent East, Southampton SO 16 7PX, United Kingdom
[3] CRUK Biomolecular Structure Group, The School of Pharmacy, University of London, London WC1N 1AX, United Kingdom - Source
Journal of medicinal chemistry (Print). 2008, Vol 51, Num 18, pp 5566-5574, 9 p ; ref : 22 ref
- CODEN
- JMCMAR
- ISSN
- 0022-2623
- Scientific domain
- Pharmacology drugs
- Publisher
- American Chemical Society, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Aminoamide Anticancéreux Cellule tumorale Col utérus Composé benzénique condensé Composé conjugué Composé tricyclique Cytotoxicité Dérivé de l'anthraquinone Embryon Homme In vitro Inhibiteur de la télomérase Inhibiteur enzyme Lignée HeLa Lignée cellulaire Nucleotidyltransferases Quinone Rein Relation structure activité Synthèse chimique Telomerase α-Aminoacide Lignée 293T Enzyme Transferases
- Keyword (en)
- Aminoamide Antineoplastic agent Tumor cell Uterine cervix Condensed benzenic compound Conjugated compound Tricyclic compound Cytotoxicity Anthraquinone derivatives Embryo Human In vitro Telomerase inhibitor Enzyme inhibitor Hela cell line Cell line Nucleotidyltransferases Quinone Kidney Structure activity relation Chemical synthesis Telomerase α-Aminoacid Enzyme Transferases
- Keyword (es)
- Aminoamida Anticanceroso Célula tumoral Cuello útero Compuesto bencénico condensado Compuesto conjugado Compuesto tricíclico Citotoxicidad Antraquinona derivado Embrión Hombre In vitro Inhibidor telomerase Inhibidor enzima Célula HeLa Línea celular Nucleotidyltransferases Quinona Riñón Relación estructura actividad Síntesis química Telomerase α-Aminoácido Enzima Transferases
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R01 General aspects
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 20687110
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
Access to the document
Install on your browser
DOI
10.1021/jm800160v 
https://dx.doi.org/10.1021/jm800160v
"O:13:\"PanistOpenUrl\":36:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000idc\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:17:\"10.1021\/jm800160v\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:110:\"Aminoacyl-Anthraquinone Conjugates as Telomerase Inhibitors : Synthesis, Biophysical and Biological Evaluation\";s:9:\"\u0000*\u0000jtitle\";s:38:\"Journal of medicinal chemistry (Print)\";s:9:\"\u0000*\u0000stitle\";s:21:\"J. med. chem. (Print)\";s:7:\"\u0000*\u0000date\";s:4:\"2008\";s:9:\"\u0000*\u0000volume\";s:2:\"51\";s:8:\"\u0000*\u0000issue\";s:2:\"18\";s:8:\"\u0000*\u0000spage\";s:4:\"5566\";s:8:\"\u0000*\u0000epage\";s:4:\"5574\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"0022-2623\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:7:\"ZAGOTTO\";s:10:\"\u0000*\u0000aufirst\";s:8:\"Giuseppe\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:7:{i:0;s:14:\"SISSI, Claudia\";i:1;s:17:\"LUCATELLO, Lorena\";i:2;s:16:\"PIVETTA, Claudia\";i:3;s:18:\"CADAMURO, Sergio A\";i:4;s:12:\"FOX, Keith R\";i:5;s:15:\"NEIDLE, Stephen\";i:6;s:15:\"PALUMBO, Manlio\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:6:\"JMCMAR\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:110:\"Aminoacyl-Anthraquinone Conjugates as Telomerase Inhibitors : Synthesis, Biophysical and Biological Evaluation\";s:8:\"\u0000*\u0000place\";s:14:\"Washington, DC\";s:6:\"\u0000*\u0000pub\";s:25:\"American Chemical Society\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:1:\"9\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
Panist access
"O:12:\"IstexOpenUrl\":35:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:17:\"10.1021\/jm800160v\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:110:\"Aminoacyl-Anthraquinone Conjugates as Telomerase Inhibitors : Synthesis, Biophysical and Biological Evaluation\";s:9:\"\u0000*\u0000jtitle\";s:38:\"Journal of medicinal chemistry (Print)\";s:9:\"\u0000*\u0000stitle\";s:21:\"J. med. chem. (Print)\";s:7:\"\u0000*\u0000date\";s:4:\"2008\";s:9:\"\u0000*\u0000volume\";s:2:\"51\";s:8:\"\u0000*\u0000issue\";s:2:\"18\";s:8:\"\u0000*\u0000spage\";s:4:\"5566\";s:8:\"\u0000*\u0000epage\";s:4:\"5574\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"0022-2623\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:7:\"ZAGOTTO\";s:10:\"\u0000*\u0000aufirst\";s:8:\"Giuseppe\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:7:{i:0;s:14:\"SISSI, Claudia\";i:1;s:17:\"LUCATELLO, Lorena\";i:2;s:16:\"PIVETTA, Claudia\";i:3;s:18:\"CADAMURO, Sergio A\";i:4;s:12:\"FOX, Keith R\";i:5;s:15:\"NEIDLE, Stephen\";i:6;s:15:\"PALUMBO, Manlio\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:6:\"JMCMAR\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:110:\"Aminoacyl-Anthraquinone Conjugates as Telomerase Inhibitors : Synthesis, Biophysical and Biological Evaluation\";s:8:\"\u0000*\u0000place\";s:14:\"Washington, DC\";s:6:\"\u0000*\u0000pub\";s:25:\"American Chemical Society\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:1:\"9\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
Istex access
"O:16:\"UnpaywallOpenUrl\":35:{s:8:\"\u0000*\u0000email\";s:27:\"assistance-portail@inist.fr\";s:6:\"\u0000*\u0000fmt\";N;s:6:\"\u0000*\u0000doi\";s:17:\"10.1021\/jm800160v\";s:6:\"\u0000*\u0000pii\";N;s:7:\"\u0000*\u0000pmid\";N;s:9:\"\u0000*\u0000atitle\";N;s:9:\"\u0000*\u0000jtitle\";N;s:9:\"\u0000*\u0000stitle\";N;s:7:\"\u0000*\u0000date\";N;s:9:\"\u0000*\u0000volume\";N;s:8:\"\u0000*\u0000issue\";N;s:8:\"\u0000*\u0000spage\";N;s:8:\"\u0000*\u0000epage\";N;s:8:\"\u0000*\u0000pages\";N;s:7:\"\u0000*\u0000issn\";N;s:8:\"\u0000*\u0000eissn\";N;s:9:\"\u0000*\u0000aulast\";N;s:10:\"\u0000*\u0000aufirst\";N;s:9:\"\u0000*\u0000auinit\";N;s:10:\"\u0000*\u0000auinitm\";N;s:5:\"\u0000*\u0000au\";N;s:9:\"\u0000*\u0000aucorp\";N;s:7:\"\u0000*\u0000isbn\";N;s:8:\"\u0000*\u0000coden\";N;s:8:\"\u0000*\u0000genre\";N;s:7:\"\u0000*\u0000part\";N;s:9:\"\u0000*\u0000btitle\";N;s:8:\"\u0000*\u0000title\";N;s:8:\"\u0000*\u0000place\";N;s:6:\"\u0000*\u0000pub\";N;s:10:\"\u0000*\u0000edition\";N;s:9:\"\u0000*\u0000tpages\";N;s:9:\"\u0000*\u0000series\";N;s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";N;}"
Unpaywall access
"O:16:\"EuropePMCOpenUrl\":35:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:17:\"10.1021\/jm800160v\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:110:\"Aminoacyl-Anthraquinone Conjugates as Telomerase Inhibitors : Synthesis, Biophysical and Biological Evaluation\";s:9:\"\u0000*\u0000jtitle\";s:38:\"Journal of medicinal chemistry (Print)\";s:9:\"\u0000*\u0000stitle\";s:21:\"J. med. chem. (Print)\";s:7:\"\u0000*\u0000date\";s:4:\"2008\";s:9:\"\u0000*\u0000volume\";s:2:\"51\";s:8:\"\u0000*\u0000issue\";s:2:\"18\";s:8:\"\u0000*\u0000spage\";s:4:\"5566\";s:8:\"\u0000*\u0000epage\";s:4:\"5574\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"0022-2623\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:7:\"ZAGOTTO\";s:10:\"\u0000*\u0000aufirst\";s:8:\"Giuseppe\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:7:{i:0;s:14:\"SISSI, Claudia\";i:1;s:17:\"LUCATELLO, Lorena\";i:2;s:16:\"PIVETTA, Claudia\";i:3;s:18:\"CADAMURO, Sergio A\";i:4;s:12:\"FOX, Keith R\";i:5;s:15:\"NEIDLE, Stephen\";i:6;s:15:\"PALUMBO, Manlio\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:6:\"JMCMAR\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:110:\"Aminoacyl-Anthraquinone Conjugates as Telomerase Inhibitors : Synthesis, Biophysical and Biological Evaluation\";s:8:\"\u0000*\u0000place\";s:14:\"Washington, DC\";s:6:\"\u0000*\u0000pub\";s:25:\"American Chemical Society\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:1:\"9\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
Europe PubMed Central access
"O:11:\"BaseOpenUrl\":35:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:17:\"10.1021\/jm800160v\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:110:\"Aminoacyl-Anthraquinone Conjugates as Telomerase Inhibitors : Synthesis, Biophysical and Biological Evaluation\";s:9:\"\u0000*\u0000jtitle\";s:38:\"Journal of medicinal chemistry (Print)\";s:9:\"\u0000*\u0000stitle\";s:21:\"J. med. chem. (Print)\";s:7:\"\u0000*\u0000date\";s:4:\"2008\";s:9:\"\u0000*\u0000volume\";s:2:\"51\";s:8:\"\u0000*\u0000issue\";s:2:\"18\";s:8:\"\u0000*\u0000spage\";s:4:\"5566\";s:8:\"\u0000*\u0000epage\";s:4:\"5574\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"0022-2623\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:7:\"ZAGOTTO\";s:10:\"\u0000*\u0000aufirst\";s:8:\"Giuseppe\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:7:{i:0;s:14:\"SISSI, Claudia\";i:1;s:17:\"LUCATELLO, Lorena\";i:2;s:16:\"PIVETTA, Claudia\";i:3;s:18:\"CADAMURO, Sergio A\";i:4;s:12:\"FOX, Keith R\";i:5;s:15:\"NEIDLE, Stephen\";i:6;s:15:\"PALUMBO, Manlio\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:6:\"JMCMAR\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:110:\"Aminoacyl-Anthraquinone Conjugates as Telomerase Inhibitors : Synthesis, Biophysical and Biological Evaluation\";s:8:\"\u0000*\u0000place\";s:14:\"Washington, DC\";s:6:\"\u0000*\u0000pub\";s:25:\"American Chemical Society\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:1:\"9\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
Base Search access
"O:12:\"ArXivOpenUrl\":35:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:17:\"10.1021\/jm800160v\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:110:\"Aminoacyl-Anthraquinone Conjugates as Telomerase Inhibitors : Synthesis, Biophysical and Biological Evaluation\";s:9:\"\u0000*\u0000jtitle\";s:38:\"Journal of medicinal chemistry (Print)\";s:9:\"\u0000*\u0000stitle\";s:21:\"J. med. chem. (Print)\";s:7:\"\u0000*\u0000date\";s:4:\"2008\";s:9:\"\u0000*\u0000volume\";s:2:\"51\";s:8:\"\u0000*\u0000issue\";s:2:\"18\";s:8:\"\u0000*\u0000spage\";s:4:\"5566\";s:8:\"\u0000*\u0000epage\";s:4:\"5574\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"0022-2623\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:7:\"ZAGOTTO\";s:10:\"\u0000*\u0000aufirst\";s:8:\"Giuseppe\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:7:{i:0;s:14:\"SISSI, Claudia\";i:1;s:17:\"LUCATELLO, Lorena\";i:2;s:16:\"PIVETTA, Claudia\";i:3;s:18:\"CADAMURO, Sergio A\";i:4;s:12:\"FOX, Keith R\";i:5;s:15:\"NEIDLE, Stephen\";i:6;s:15:\"PALUMBO, Manlio\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:6:\"JMCMAR\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:110:\"Aminoacyl-Anthraquinone Conjugates as Telomerase Inhibitors : Synthesis, Biophysical and Biological Evaluation\";s:8:\"\u0000*\u0000place\";s:14:\"Washington, DC\";s:6:\"\u0000*\u0000pub\";s:25:\"American Chemical Society\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:1:\"9\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
arXiv access
