A β-Fluoroamine Inhibitor of Purine Nucleoside Phosphorylase
- Author
- MASON, Jennifer M1 ; MURKIN, Andrew S2 ; LEI LI2 ; SCHRAMM, Vem L2 ; GAINSFORD, Graeme J1 ; SKELTON, Brian W3
[1] Carbohydrate Chemistry Team, Industrial Research Limited, P O Box 31310, Lower Hutt, New Zealand
[2] Department of Biochemistry, Albert Einstein College of Medicine of Yeshiva University, 1300 Morris Park Avenue, Bronx, New York 10461, United States
[3] Chemistry, M313, School of Biomedical, Biomolecular and Chemical Sciences, University of Western Australia, Crawley 6006, Australia - Source
Journal of medicinal chemistry (Print). 2008, Vol 51, Num 18, pp 5880-5884, 5 p ; ref : 44 ref
- CODEN
- JMCMAR
- ISSN
- 0022-2623
- Scientific domain
- Pharmacology drugs
- Publisher
- American Chemical Society, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Animal Biodisponibilité C-Nucléoside Composé bicyclique Dérivé de la pyrrolidine Enantiomère Halogénoalcool Homme Hétérocycle azote Iminoalditol Immunomodulateur In vitro In vivo Inhibiteur enzyme Pharmacocinétique Purine-nucleoside phosphorylase Racémique Souris Synthèse chimique Voie orale Immucilline dérivé Pyrrolo[3,2-d]pyrimidin-4-one(7-[(3-fluoro-4-hydroxy-3-[hydroxyméthyl]pyrrolidino)méthyl]) Pyrrolo[3,2-d]pyrimidine dérivé Pyrrolopyrimidine Enzyme Fluor Composé organique Glycosyltransferases Mammalia Pentosyltransferases Rodentia Transferases Vertebrata
- Keyword (en)
- Animal Bioavailability C-Nucleoside Bicyclic compound Pyrrolidine derivatives Enantiomer Haloalcohol Human Nitrogen heterocycle Iminoalditol Immunomodulator In vitro In vivo Enzyme inhibitor Pharmacokinetics Purine-nucleoside phosphorylase Racemic Mouse Chemical synthesis Oral administration Enzyme Fluorine Organic compounds Glycosyltransferases Mammalia Pentosyltransferases Rodentia Transferases Vertebrata
- Keyword (es)
- Animal Biodisponibilidad C-Nucleósido Compuesto bicíclico Enantiómero Haloalcohol Hombre Heterociclo nitrógeno Iminoalditol Inmunomodulador In vitro In vivo Inhibidor enzima Farmacocinética Purine-nucleoside phosphorylase Racémico Ratón Síntesis química Vía oral Enzima Fluor Compuesto orgánico Glycosyltransferases Mammalia Pentosyltransferases Rodentia Transferases Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02Q Immunomodulators
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 20687143
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1021/jm800792b 
https://dx.doi.org/10.1021/jm800792b
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