Simultaneous Determination of Ramipril and Its Active Metabolite Ramiprilat in Human Plasma by LC-MS-MS
- Author
- BO YUAN1 ; XUAN WANG1 ; FENGE ZHANG1 ; JUN JIA1 ; FANGLING TANG1
[1] Department of Analytical Chemistry, Shenyang Pharmaceutical University, 103 Wenhua Road, 110016 Shenyang, China - Source
Chromatographia (Wiesbaden). 2008, Vol 68, Num 7-8, pp 533-539, 7 p ; ref : 17 ref
- CODEN
- CHRGB7
- ISSN
- 0009-5893
- Scientific domain
- Analytical chemistry
- Publisher
- Springer, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Author keyword
- Column liquid chromatography tandem mass spectrometry Pharmacokinetic study Ramipril and ramiprilat
- Keyword (fr)
- Analyse chimique Analyse quantitative Antihypertenseur Chromatographie HPLC Chromatographie phase inverse Condition isocratique Dipeptide Electrospray Extraction liquide liquide Extraction solvant Homme Liquide biologique Mesure simultanée Métabolite Méthode couplée Normal Peptide Pharmacocinétique Plasma sanguin Ramipril Ramiprilate Sang Validation Voie orale Cyclopenta[b]pyrrole-2-carboxylique acide dérivé Cyclopentapyrrole LC MS MS Spectrométrie masse tandem Enzyme Hydrolases Inhibiteur angiotensin converting enzyme Inhibiteur enzyme Peptidases Peptidyl-dipeptidase A Peptidyl-dipeptidases
- Keyword (en)
- Chemical analysis Quantitative analysis Antihypertensive agent HPLC chromatography Reversed phase chromatography Isocratic condition Dipeptides Electrospray Liquid liquid extraction Solvent extraction Human Biological fluid Simultaneous measurement Metabolite Coupled method Normal Peptides Pharmacokinetics Blood plasma Ramipril Ramiprilat Blood Validation Oral administration Tandem mass spectrometry Enzyme Hydrolases ACE inhibitor Enzyme inhibitor Peptidases Peptidyl-dipeptidase A Peptidyl-dipeptidases
- Keyword (es)
- Análisis químico Análisis cuantitativo Antihipertensivo Cromatografía HPLC Cromatografía fase inversa Condición isocrática Dipéptido Electrospray Extracción líquido líquido Extracción solvente Hombre Líquido biológico Medición simultánea Metabolito Método acoplado Normal Péptido Farmacocinética Plasma sanguíneo Ramipril Ramiprilat Sangre Validación Vía oral Espectrometría masa en tándem Enzima Hydrolases Inhibidor angiotensin converting enzyme Inhibidor enzima Peptidases Peptidyl-dipeptidase A Peptidyl-dipeptidases
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02A General pharmacology / 002B02A02 Analysis
- Discipline
- General pharmacology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 20759054
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1365/s10337-008-0757-5 
https://dx.doi.org/10.1365/s10337-008-0757-5
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