(3R)-3-Amino-4-( 2,4,5 -trifluorophenyl)-N-{4-[6-(2-methoxyethoxy)benzothiazol-2-yl]tetrahydropyran-4-ylbutanamide as a potent dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes
- Author
- NITTA, Aiko1 ; FUJII, Hideaki1 ; KUMAGAI, Hiroki1 ; SHIMAMURA, Masahiro1 ; FUKAZAWA, Tominaga1 ; KAWAI, Hideki1 ; SAKAMI, Satoshi1 ; NISHIMURA, Yutaka1 ; OHYAMA, Tomofumi1 ; SATOH, Mikiya1 ; NAKAKI, Junko1 ; SATOH, Shiho1 ; INADA, Chifumi1 ; KOZONO, Hideki1
[1] Pharmaceutical Research Laboratories, Toray Industries Inc., 6-10-1, Tebiro, Kamakura, Kanagawa 248-8555, Japan - Source
Bioorganic & medicinal chemistry letters (Print). 2008, Vol 18, Num 20, pp 5435-5438, 4 p ; ref : 22 ref
- ISSN
- 0960-894X
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Amsterdam
- Publication country
- Netherlands
- Document type
- Article
- Language
- English
- Keyword (fr)
- Aminoamide Animal Chimiothérapie Composé aromatique Composé bicyclique Diabète de type 2 Dipeptidyl-peptidase IV Diéther Dérivé du benzothiazole Dérivé du pyrane Homme Hyperglycémie provoquée Hypoglycémiant Hétérocycle oxygène Hétérocycle soufre azote In vitro In vivo Inhibiteur enzyme Relation structure activité Souris Synthèse chimique Voie orale Antidiabétique Benzènebutyramide(β-amino-N-[4-(6-[2-méthoxyéthoxy]benzothiazol-2-yl)-tétrahydropyran-4-yl]-2,4,5-trifluoro) Inhibiteur DPIV Enzyme Fluor Composé organique Hydrolases Mammalia Peptidases Rodentia Traitement Vertebrata
- Keyword (en)
- Aminoamide Animal Chemotherapy Aromatic compound Bicyclic compound Type 2 diabetes Dipeptidyl-peptidase IV Diether Benzothiazole derivatives Pyran derivatives Human Glucose tolerance test Hypoglycemic agent Oxygen heterocycle Sulfur nitrogen heterocycle In vitro In vivo Enzyme inhibitor Structure activity relation Mouse Chemical synthesis Oral administration Enzyme Fluorine Organic compounds Hydrolases Mammalia Peptidases Rodentia Treatment Vertebrata
- Keyword (es)
- Aminoamida Animal Quimioterapia Compuesto aromático Compuesto bicíclico Diabetes de tipo 2 Dipeptidyl-peptidase IV Dieter Benzotiazol derivado Pirano derivado Hombre Hiperglicemia provocada Hipoglicemiante Heterociclo oxígeno Heterociclo azufre nitrógeno In vitro In vivo Inhibidor enzima Relación estructura actividad Ratón Síntesis química Vía oral Enzima Fluor Compuesto orgánico Hydrolases Mammalia Peptidases Rodentia Tratamiento Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02N General and cellular metabolism. Vitamins
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 20798083
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmcl.2008.09.042 
https://dx.doi.org/10.1016/j.bmcl.2008.09.042
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