Design at the atomic level : Design of biaryloxazolidinones as potent orally active antibiotics
- Author
- JIACHENG ZHOU1 ; BHATTACHARJEE, Ashoke1 ; ORBIN, Alia1 ; OYELERE, Ayomi1 ; SALVINO, Joe1 ; SPRINGER, Dane1 ; TRAN, Jennifer1 ; DEPING WANG2 ; YUSHENG WU1 ; JOHNSON, Graham1 2 ; SHILI CHEN1 ; YI CHEN1 ; DUFFY, Erin2 ; FARMER, Jay1 ; GOLDBERG, Joel1 ; HANSELMANN, Roger1 ; IPPOLITO, Joseph A2 ; RONGLIANG LOU1
[1] Department of Medicinal Chemistry, Rib-X Pharmaceuticals Inc., 300 George Street. Suite 301, New Haven, CT 06511, United States
[2] Department of Structure-Based Drug Design, Rib-X Pharmaceuticals Inc., 300 George Street, Suite 301, New Haven, CT 06511, United States - Source
Bioorganic & medicinal chemistry letters (Print). 2008, Vol 18, Num 23, pp 6175-6178, 4 p
- ISSN
- 0960-894X
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Amsterdam
- Publication country
- Netherlands
- Document type
- Article
- Language
- English
- Author keyword
- Biaryloxazolidinone Gram-negative bacteria Hybrid antibiotics Linezolid Oral antibiotics Oxazolidinone Ribosome Sparsomycin Structure-based drug design X-ray crystal structure
- Keyword (fr)
- Aminonitrile Antibactérien Bactérie Gram négatif Bactérie Gram positif Biodisponibilité Carbamate organique Carboxamide Dérivé de l'isoxazole Dérivé de l'oxazolidinone Dérivé du biphényle Dérivé du triazole Dérivé du tétrazole Hétérocycle azote Hétérocycle oxygène azote Linézolide Relation structure activité Résistance Synthèse chimique Voie orale Acétamide dérivé Oxazolidin-2-one dérivé Souche résistante linézolide Fluor Composé organique
- Keyword (en)
- Aminonitrile Antibacterial agent Gram negative bacteria Gram positive bacteria Bioavailability Organic carbamate Carboxamide Isoxazole derivatives Oxazolidinone derivative Biphenyl derivatives Triazole derivatives Tetrazole derivatives Nitrogen heterocycle Oxygen nitrogen heterocycle Linezolid Structure activity relation Resistance Chemical synthesis Oral administration Fluorine Organic compounds
- Keyword (es)
- Aminonitrilo Antibacteriano Bacteria Gram negativa Bacteria Gram positiva Biodisponibilidad Carbamato orgánico Carboxamida Oxazolidinona derivado Bifenilo derivado Triazol derivado Tetrazol derivado Heterociclo nitrógeno Heterociclo oxígeno nitrógeno Linezolid Relación estructura actividad Resistencia Síntesis química Vía oral Fluor Compuesto orgánico
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02S Antibiotics. Antiinfectious agents. Antiparasitic agents / 002B02S02 Antibacterial agents
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 20876323
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmcl.2008.10.011 
https://dx.doi.org/10.1016/j.bmcl.2008.10.011
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