A Nonpeptide, Piperidine Renin Inhibitor Provides Renal and Cardiac Protection in Double-Transgenic Mice Expressing Human Renin and Angiotensinogen Genes
- Author
- MAJOR, Terry C1 ; OLSZEWSKI, Bronia1 ; ROSEBURY, Wendy1 ; OKERBERG, Carlin2 ; CARLSON, Tage2 ; OSTROSKI, Robert1 ; SCHROEDER, Richard1 ; KOWALA, Mark C1 ; LEADLEY, Robert1
[1] Cardiovascular and Atherosclerosis Biology, Pfizer Global Research & Development, Pfizer, Inc., 2800 Plymouth Road, Ann Arbor, MI 48105, United States
[2] Drug Safety Research and Development, Pfizer Global Research & Development, Pfizer, Inc., 2800 Plymouth Road, Ann Arbor, MI 48105, United States - Source
Cardiovascular drugs and therapy. 2008, Vol 22, Num 6, pp 469-478, 10 p ; ref : 38 ref
- CODEN
- CDTHET
- ISSN
- 0920-3206
- Scientific domain
- Cardiology, blood circulation, phlebology; Pharmacology drugs
- Publisher
- Springer, Dordrecht
- Publication country
- Netherlands
- Document type
- Article
- Language
- English
- Author keyword
- Candesartan Cardioprotection Enalapril Hypertensive Double Transgenic Mice Left Ventricular Hypertrophy and Microalbuminuria Renin Inhibitor Renoprotection
- Keyword (fr)
- Animal transgénique Antihypertenseur Candésartan Cardioprotecteur Composé non peptide Dérivé de la pipéridine Enalapril Homme Hypertension artérielle Microalbuminurie Souris Inhibiteur de la rénine Récepteur AT1 de l'angiotensine II Angiotensine II Antagoniste angiotensine Appareil urinaire Dérivé de l'imidazole Dérivé du biphényle Dérivé du tétrazole Génétique Hormone peptide Inhibiteur angiotensin converting enzyme Mammalia Pathologie de l'appareil circulatoire Pathologie de l'appareil urinaire Prohormone Rodentia Sartan dérivé Système renin angiotensine Vertebrata
- Keyword (en)
- Transgenic animal Antihypertensive agent Candesartan Cardioprotective agent Non peptide compound Piperidine derivatives Enalapril Human Hypertension Microalbuminuria Mouse Renin inhibitor Angiotensin II Angiotensin antagonist Urinary system Imidazole derivatives Biphenyl derivatives Tetrazole derivatives Genetics Peptide hormone ACE inhibitor Mammalia Cardiovascular disease Urinary system disease Prohormone Rodentia Sartan derivatives Renin angiotensin system Vertebrata
- Keyword (es)
- Animal transgénico Antihipertensivo Candesartán Cardioprotector Compuesto no péptido Piperidina derivado Enalapril Hombre Hipertensión arterial Microalbuminuria Ratón Inhibidor de renina Angiotensina II Antagonista angiotensina Aparato urinario Imidazol derivado Bifenilo derivado Tetrazol derivado Genética Hormona péptido Inhibidor angiotensin converting enzyme Mammalia Aparato circulatorio patología Aparato urinario patología Prohormona Rodentia Sartan derivado Sistema renin angiotensina Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02F Cardiovascular system / 002B02F05 Antihypertensive agents
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B12 Cardiology. Vascular system / 002B12B Blood and lymphatic vessels / 002B12B05 Arterial hypertension. Arterial hypotension
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B14 Nephrology. Urinary tract diseases / 002B14E Urinary system involvement in other diseases. Miscellaneous / 002B14E02 Urinary tract. Prostate gland
- Discipline
- Cardiology. Circulatory system Nephrology. Urinary tract diseases Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 20902553
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1007/s10557-008-6131-x 
https://dx.doi.org/10.1007/s10557-008-6131-x
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