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Polymorphisms of drug-metabolizing enzymes (GST, CYP2B6 and CYP3A) affect the pharmacokinetics of thiotepa and tepa

Author
EKHART, Corine1 ; DOODEMAN, Valerie D1 ; RODENBUIS, Sjoerd2 ; SMITS, Paul H. M3 ; BEIJNEN, Jos H1 4 ; HUITEMA, Alwin D. R1
[1] Department of Pharmacy & Pharmacology, The Netherlands Cancer Institute/Slotervaart Hospital, Netherlands
[2] Department ofMedical Oncology, the Netherlands Cancer Istitute/Antonivan Leewenhoek Hospital, Netherlands
[3] Departmentof Molecular Biology, Slotervaart Hospital, Amsterdam, Netherlands
[4] Faculty of Pharmaceutical Sciences, Department of Biomedical Analysis, Section of Drug Toxicology, Ultrecht University, Ultrcht, Netherlands
Source

British journal of clinical pharmacology. 2009, Vol 67, Num 1 ; 50-60, 145 [12 p.] ; ref : 50 ref

CODEN
BCPHBM
ISSN
0306-5251
Scientific domain
Pharmacology drugs
Publisher
Blackwell, Oxford
Publication country
United Kingdom
Document type
Article
Language
English
Author keyword
pharmacogenetics population pharmacokinetics tepa thiotepa
Keyword (fr)
Anticancéreux Cytochrome P450 Drug-metabolizing enzyme Glutathione transferase Génotype Isozyme Pharmacocinétique de la population Pharmacogénétique Polymorphisme Tepa Thiotépa Variabilité génétique Cytochrome P450 2B6 Cytochrome P450 3A Agent alkylant Dérivé de l'aziridine Enzyme Génétique Phosphorotriamide organique Thiophosphoramidate organique Transferases
Keyword (en)
Antineoplastic agent Cytochrome P450 Drug-metabolizing enzyme Glutathione transferase Genotype Isozyme Population pharmacokinetics Pharmacogenetics Polymorphism Thiotepa Genetic variability Cytochrome P450 2B6 Alkylating agent Aziridine derivatives Enzyme Genetics Organic phosphorotriamide Organic thioamidophosphate Transferases
Keyword (es)
Anticanceroso Citocromo P450 Drug-metabolizing enzyme Glutathione transferase Genotipo Isozima Farmacocinética población Farmacogenética Polimorfismo Tiotepa Variabilidad genética Cytochrome P450 2B6 Agente alquilante Enzima Genética Fosforotriamida orgánica Tiofosforamidato orgánico Transferases
Classification
Pascal
002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments

Discipline
General pharmacology
Origin
Inist-CNRS
Database
PASCAL
INIST identifier
20976359

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS

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