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Pleuromutilin derivatives having a purine ring. Part 2: Influence of the central spacer on the antibacterial activity against Gram-positive pathogens

Author
HIROKAWA, Yoshimi1 ; KINOSHITA, Hironori1 ; TANAKA, Tomoyuki1 ; NAKAMURA, Takanori1 ; FUJIMOTO, Koichi2 ; KASHIMOTO, Shigeki2 ; KOJIMA, Tsuyoshi2 ; KATO, Shiro1
[1] Chemistry Research Laboratories, Dainippon Sumitomo Pharma Co., Ltd, Enoki 33-94, Suita 564-0053, Japan
[2] Pharmacology Research Laboratories, Dainippon Sumitomo Pharma Co., Ltd, 3-1-98 Kasugade Naka, Konohana-ku, Osaka 554-0022, Japan
Source

Bioorganic & medicinal chemistry letters (Print). 2009, Vol 19, Num 1, pp 170-174, 5 p ; ref : 16 ref

ISSN
0960-894X
Scientific domain
Biochemistry, molecular biology, biophysics; Pharmacology drugs
Publisher
Elsevier, Amsterdam
Publication country
Netherlands
Document type
Article
Language
English
Author keyword
Gram-positive bacteria MIC MRSA PRSP Piperazine ring Pleuromutilin Purine ring Spacer Sulfide VRE
Keyword (fr)
Activité biologique Animal Antibactérien Bactérie Gram positif Carboxamide Diterpène Dérivé de la pipérazine Dérivé de la pipéridine Dérivé de la purine Dérivé de la pyrrolidine Enterococcus Ester In vitro In vivo Méticilline Pathogène Pénicilline Résistance Souris Staphylococcus aureus Streptococcus pneumoniae Synthèse chimique Terpénoïde 3a,9-Propanocyclopentacycloctène dérivé Bras espaceur Pleuromutiline Souche résistante méticilline Souche résistante pénicilline Bactérie Mammalia Micrococcaceae Micrococcales Rodentia Streptococcaceae Vertebrata
Keyword (en)
Biological activity Animal Antibacterial agent Gram positive bacteria Carboxamide Diterpene Piperazine derivatives Piperidine derivatives Purine derivatives Pyrrolidine derivatives Enterococcus Ester In vitro In vivo Meticillin Pathogenic Penicillin Resistance Mouse Staphylococcus aureus Streptococcus pneumoniae Chemical synthesis Terpenoid Spacer arm Bacteria Mammalia Micrococcaceae Micrococcales Rodentia Streptococcaceae Vertebrata
Keyword (es)
Actividad biológica Animal Antibacteriano Bacteria Gram positiva Carboxamida Diterpeno Piperazina derivado Piperidina derivado Purina derivado Enterococcus Ester In vitro In vivo Meticilina Patógeno Penicilina Resistencia Ratón Staphylococcus aureus Streptococcus pneumoniae Síntesis química Terpenoide Bacteria Mammalia Micrococcaceae Micrococcales Rodentia Streptococcaceae Vertebrata
Classification
Pascal
002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02S Antibiotics. Antiinfectious agents. Antiparasitic agents / 002B02S02 Antibacterial agents

Discipline
Pharmacological treatments
Origin
Inist-CNRS
Database
PASCAL
INIST identifier
21030115

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS

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