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Population Pharmacokinetics of Sildenafil in Term Neonates : Evidence of Rapid Maturation of Metabolic Clearance in the Early Postnatal Period

Author
MUKHERJEE, A1 ; DOMBI, T1 ; WITTKE, B1 ; LALONDE, R1
[1] Pfizer Global Research and Development, Clinical Development, New London, Connecticut, United States
Source

Clinical pharmacology and therapeutics. 2009, Vol 85, Num 1, pp 56-63, 8 p ; ref : 31 ref

CODEN
CLPTAT
ISSN
0009-9236
Scientific domain
Pharmacology drugs
Publisher
Nature Publishing Group, Basingstoke
Publication country
United Kingdom
Document type
Article
Language
English
Keyword (fr)
Clairance Métabolisme Nouveau né Pharmacocinétique de la population Postnatal Précoce Sildénafil Vasodilatateur 3',5'-Cyclic-GMP phosphodiesterase Enzyme Esterases Homme Hydrolases Inhibiteur de la phosphodiesterase Inhibiteur de la phosphodiestérase 5 Inhibiteur enzyme Phosphoric diester hydrolases
Keyword (en)
Clearance Metabolism Newborn Population pharmacokinetics Postnatal Early Sildenafil Vasodilator agent 3',5'-Cyclic-GMP phosphodiesterase Enzyme Esterases Human Hydrolases Phosphodiesterase inhibitor Phosphodiesterase 5 inhibitor Enzyme inhibitor Phosphoric diester hydrolases
Keyword (es)
Depuración Metabolismo Recién nacido Farmacocinética población Postnatal Precoz Sildenafilo Vasodilatador 3',5'-Cyclic-GMP phosphodiesterase Enzima Esterases Hombre Hydrolases Inhibidor phosphodiesterase Inhibidor fosfodiesterasa 5 Inhibidor enzima Phosphoric diester hydrolases
Classification
Pascal
002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments

Discipline
General pharmacology
Origin
Inist-CNRS
Database
PASCAL
INIST identifier
21127299

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS

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