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The Liver Toxicity Biomarker Study : Phase I Design and Preliminary Results

MCBURNEY, Robert N1 ; HINES, Wade M1 ; ZHENQIANG SU2 ; FAN, Xiau-Hut2 ; WEIDA TONG2 ; BOOTH, Shelagh A1 ; BALASUBRAMANIAN, Raji1 ; COURCHESNE, Paul L1 ; CAMPBELL, Jennifer M1 ; GRABER, Armin1 ; YU GUO1 ; JUHASZ, Peter J1 ; VON TUNGELN, Linda S2 ; LI, Tricin Y1 ; LYNCH, Moira D1 ; MUREL, Nicole M1 ; PLASTERER, Thomas N1 ; TAKACH, Edward J1 ; CHENHUI ZENG1 ; BELAND, Frederick A2 ; SCHNACKENBERG, Laura K2 ; BEGER, Richard D2 ; MOLAND, Carrie L2 ; TAO HAN2 ; FUSCOE, James C2 ; CHANG, Ching-Wei2 ; CHEN, James J2
[1] BG Medicine, Inc, Waltham, MA, United States
[2] National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, United States
Conference title
Society of Toxicologic Pathology's 27th Annual Symposium Presentations
Conference name
Society of Toxicologic Pathology's. Annual Symposium Presentations (27 )
Author (monograph)
Society of Toxicologic Pathology, United States (Organiser of meeting)

Toxicologic pathology. 2009, Vol 37, Num 1, pp 52-64, 13 p ; ref : 3/4 p

Scientific domain
General medicine general surgery; Pharmacology drugs; Toxicology
Sage Publications, Thousand Oaks, CA
Publication country
United States
Document type
Conference Paper
Author keyword
biomarker entacapone liver toxicity tolcapone
Keyword (fr)
Antiparkinsonien Conception Entacapone Essai clinique phase I Foie Marqueur biologique Tolcapone Toxicité Traitement Inhibiteur de la catéchol-O-méthyltransférase Appareil digestif Catechol O-methyltransferase Enzyme Inhibiteur enzyme Methyltransferases Transferases
Keyword (en)
Antiparkinson agent Design Entacapone Phase I trial Liver Biological marker Tolcapone Toxicity Treatment Digestive system Catechol O-methyltransferase Enzyme Enzyme inhibitor Methyltransferases Transferases
Keyword (es)
Antiparkinsoniano Diseño Entacapona Ensayo clínico fase I Hígado Marcador biológico Tolcapona Toxicidad Tratamiento Aparato digestivo Catechol O-methyltransferase Enzima Inhibidor enzima Methyltransferases Transferases
002 Biological and medical sciences / 002B Medical sciences / 002B03 Toxicology

INIST identifier

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS

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