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The Role of Protease Inhibitors in the Pathogenesis of HIV-Associated Lipodystrophy : Cellular Mechanisms and Clinical Implications

FLINT, Oliver P1 ; NOOR, Mustafa A2 ; HRUZ, Paul W3 ; HYLEMON, Phil B4 ; YARASHESKI, Kevin5 ; KOTLER, Donald P6 ; PARKER, Rex A1 ; BELLAMINE, Aouatef1
[1] Pharmaceutical Research and Development, Bristol-Myers Squibb Company, Princeton, New Jersey, United States
[2] GlaxoSmithKline, King of Prussia, Pennsylvania, United States
[3] Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri, United States
[4] Department of Microbiology and Immunology, Virginia Commonwealth University, Richmond, Virginia, United States
[5] Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States
[6] Department of Medicine, St. Luke's-Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons, New York, New York, United States
Conference title
Society of Toxicologic Pathology's 27th Annual Symposium Presentations
Conference name
Society of Toxicologic Pathology's. Annual Symposium Presentations (27 )
Author (monograph)
Society of Toxicologic Pathology, United States (Organiser of meeting)

Toxicologic pathology. 2009, Vol 37, Num 1, pp 65-77, 13 p ; ref : 3 p.1/2

Scientific domain
General medicine general surgery; Pharmacology drugs; Toxicology
Sage Publications, Thousand Oaks, CA
Publication country
United States
Document type
Conference Paper
Author keyword
cardiovascular disease clinical pathology dyslipidemia endocrine system in vitro toxicology insulin resistance lipodystrophy mechanisms of toxicity molecular pathology pharmaceutical development/products protease inhibitors
Keyword (fr)
Anatomopathologie Dyslipémie Développement produit Endocrinologie Glande endocrine Génétique In vitro Inhibiteur protease Insuline Insulinorésistance Lipide Lipodystrophie Mécanisme action Médicament Pathogénie Pathologie de l'appareil circulatoire Résistance tissu cible SIDA Toxicité Toxicologie Virus immunodéficience humaine Endocrinopathie Hormone pancréatique Immunodéficit Immunopathologie Infection Lentivirus Maladie métabolique Pathologie de la peau Pathologie du tissu adipeux Retroviridae Virose Virus
Keyword (en)
Anatomic pathology Dyslipemia Product development Endocrinology Endocrine gland Genetics In vitro Protease inhibitor Insulin Insulin resistance Lipids Lipodystrophy Mechanism of action Drug Pathogenesis Cardiovascular disease Target tissue resistance AIDS Toxicity Toxicology Human immunodeficiency virus Endocrinopathy Pancreatic hormone Immune deficiency Immunopathology Infection Lentivirus Metabolic diseases Skin disease Adipose tissue disorders Retroviridae Viral disease Virus
Keyword (es)
Anatomía patológica Dislipemia Desarrollo producto Endocrinología Glándula endocrina Genética In vitro Inhibidor proteasa Insulina Resistancia insulina Lípido Lipodistrofia Mecanismo acción Medicamento Patogenia Aparato circulatorio patología Resistencia tejido blanco SIDA Toxicidad Toxicología Human immunodeficiency virus Endocrinopatía Hormona pancreática Inmunodeficiencia Inmunopatología Infección Lentivirus Metabolismo patología Piel patología Tejido adiposo patología Retroviridae Virosis Virus
002 Biological and medical sciences / 002B Medical sciences / 002B03 Toxicology

002 Biological and medical sciences / 002B Medical sciences / 002B05 Infectious diseases / 002B05C Viral diseases / 002B05C02 Human viral diseases / 002B05C02D Viral diseases of the lymphoid tissue and the blood. Aids

002 Biological and medical sciences / 002B Medical sciences / 002B06 Immunopathology / 002B06D Immunodeficiencies. Immunoglobulinopathies / 002B06D01 Immunodeficiencies

002 Biological and medical sciences / 002B Medical sciences / 002B08 Dermatology / 002B08J Skin involvement in other diseases. Miscellaneous. General aspects

Dermatology Immunopathology Infectious pathology Toxicology
INIST identifier

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS

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