Overcoming extractability hurdles of a 14C labeled taxane analogue milataxel and its metabolite from xenograft mouse tumor and brain tissues
- Author
- SAFARPOUR, Hudan1 ; CONNOLLY, Paul2 ; TONG, Xiaojie1 ; BIELAWSKI, Mike1 ; WILCOX, Everett1
[1] Analytical R&D, Taxolog Inc., 10 Industrial Road, Fairfield, NJ 07004, United States
[2] MPI Research, Exygen Research Division, 3058 Research Drive, State College, PA 16801, United States - Source
Journal of pharmaceutical and biomedical analysis. 2009, Vol 49, Num 3, pp 774-779, 6 p ; ref : 12 ref
- CODEN
- JPBADA
- ISSN
- 0731-7085
- Scientific domain
- Medical laboratory techniques; Pharmacology drugs
- Publisher
- Elsevier, Amsterdam
- Publication country
- Netherlands
- Document type
- Article
- Language
- English
- Author keyword
- 14C labeled taxane Brain Cytotoxic Extractability HPLC-MS Milataxel Tumors
- Keyword (fr)
- Animal Anticancéreux Carbone Isotope Cytotoxicité Diterpène Dérivé du taxane Encéphale Intracrânien Marquage radioisotopique Milataxel Métabolite Souris Système nerveux central Terpénoïde Tissu Tumeur intracrânienne Tumeur maligne Carbone 14 LC MS Cancer Mammalia Pathologie de l'encéphale Pathologie du système nerveux central Pathologie du système nerveux Rodentia Vertebrata
- Keyword (en)
- Animal Antineoplastic agent Carbon Isotopes Cytotoxicity Diterpene Taxane derivatives Encephalon Intracranial Radiolabelling Milataxel Metabolite Mouse Central nervous system Terpenoid Tissue Intracranial tumor Malignant tumor Cancer Mammalia Cerebral disorder Central nervous system disease Nervous system diseases Rodentia Vertebrata
- Keyword (es)
- Animal Anticanceroso Carbono Isótopo Citotoxicidad Diterpeno Taxane derivado Encéfalo Intracraneal Marcación radioisotópica Milataxel Metabolito Ratón Sistema nervioso central Terpenoide Tejido Tumor intracraneal Tumor maligno Cáncer Mammalia Encéfalo patología Sistema nervosio central patología Sistema nervioso patología Rodentia Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002A Fundamental and applied biological sciences. Psychology / 002A02 Analytical, structural and metabolic biochemistry
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02A General pharmacology / 002B02A02 Analysis
- Discipline
- Analytical, structural and metabolic biochemistry General pharmacology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 21289949
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.jpba.2008.12.034 
https://dx.doi.org/10.1016/j.jpba.2008.12.034
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