Glioma-Derived Mutations in IDH1 Dominantly Inhibit IDH1 Catalytic Activity and Induce HIF-1α
- Author
- SHIMIN ZHAO1 2 ; YAN LIN1 ; JIANPING DING5 ; QUNYING LEI1 6 ; GUAN, Kun-Liang1 6 7 ; YUE XIONG1 2 8 ; WEI XU1 2 ; WENQING JIANG1 2 ; ZHENGYU ZHA1 ; PU WANG1 2 ; WEI YU1 2 ; ZHIQIANG LI3 ; LINGLING GONG4 ; YINGJIE PENG5
[1] Molecular and Cell Biology Laboratory, Institute of Biomedical Sciences, Fudan University, 130 Dong-An Road, Shanghai 200032, China
[2] School of Life Sciences, Fudan University, 220 Han-Dan Road, Shanghai 200433, China
[3] Department of Neurosurgery, Zhongnan Hospital, Wuhan University, Wuhan 430071, China
[4] Department of Pathology, Zhongnan Hospital, Wuhan University, Wuhan 430071, China
[5] State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China
[6] Department of Biological Chemistry, School of Medicine, Fudan University, 130 Dong-An Road, Shanghai 200032, China
[7] Department of Pharmacology and Moores Cancer Center, University of California San Diego, La jolla, CA 92093, United States
[8] Department of Biochemistry and Biophysics, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, United States - Source
Science (Washington, D.C.). 2009, Vol 324, Num 5924, pp 261-265, 5 p
- CODEN
- SCIEAS
- ISSN
- 0036-8075
- Scientific domain
- Multidisciplinary
- Publisher
- American Association for the Advancement of Science, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Cancer du cerveau Cancérologie Carcinogenèse Gliome malin Gène suppresseur tumeur Homme Inactivation Isocitrate dehydrogenase (NAD+) Mutation Tumorigénicité Cancer Enzyme Génétique Oxidoreductases Pathologie de l'encéphale Pathologie du système nerveux central Pathologie du système nerveux Tumeur maligne
- Keyword (en)
- Brain cancer Cancerology Carcinogenesis Malignant glioma Tumor suppressor gene Human Inactivation Isocitrate dehydrogenase (NAD+) Mutation Tumorigenicity Cancer Enzyme Genetics Oxidoreductases Cerebral disorder Central nervous system disease Nervous system diseases Malignant tumor
- Keyword (es)
- Cáncer cerebro Cancerología Carcinogénesis Glioma maligno Gen supresor tumor Hombre Inactivación Isocitrate dehydrogenase (NAD+) Mutación Tumorigenicidad Cáncer Enzima Genética Oxidoreductases Encéfalo patología Sistema nervosio central patología Sistema nervioso patología Tumor maligno
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B17 Neurology / 002B17E Tumors of the nervous system. Phacomatoses
- Discipline
- Neurology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 21370176
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1126/science.1170944 
https://dx.doi.org/10.1126/science.1170944
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