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Polysaccharide nanogel delivery of a TNF-α and RANKL antagonist peptide allows systemic prevention of bone loss

Author
ALLES, Neil1 2 ; SOYSA, Niroshani S1 ; HUSSAIN, Anower1 ; TOMOMATSU, Nobuyoshi1 ; SAITO, Hiroaki3 ; BARON, Roland3 ; MORIMOTO, Nobuyuki4 ; AOKI, Kazuhiro1 ; AKIYOSHI, Kazunari2 4 ; OHYA, Keiichi1
[1] Section of Pharmacology, Department of Hard Tissue Engineering, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549, Japan
[2] Global Center of Excellence (G-COE) Program, Tokyo Medical and Dental University, Japan
[3] Harvard School of Dental Medicine and Harvard Medical School, Boston, MA 02115, United States
[4] Organic Biomaterials, Institute of Biomaterials and Bioengineering, Graduate School, Tokyo Medical & Dental University, Tokyo, Japan
Source

European journal of pharmaceutical sciences. 2009, Vol 37, Num 2, pp 83-88, 6 p ; ref : 1/2 p

ISSN
0928-0987
Scientific domain
Pharmacology drugs
Publisher
Elsevier, Kindlington
Publication country
United Kingdom
Document type
Article
Language
English
Author keyword
Aggregation Cholesterol-bearing pullulan Drug delivery system Nanogel Peptide drugs Stability
Keyword (fr)
Agrégation Antagoniste Cholestérol Facteur nécrose tumorale α Modalité traitement Médicament Nanogel Ostéopénie Peptide Perte de substance osseuse Polyoside Prévention Stabilité Technologie pharmaceutique Vecteur médicament Voie administration Pullulane Cytokine Pathologie du système ostéoarticulaire Propriété physicochimique
Keyword (en)
Aggregation Antagonist Cholesterol Tumor necrosis factor α Application method Drug Nanogel Osteopenia Peptides Bone defect Polysaccharide Prevention Stability Pharmaceutical technology Drug carrier Route of administration Pullulan Cytokine Diseases of the osteoarticular system Physicochemical properties
Keyword (es)
Agregación Antagonista Colesterol Factor necrosis tumoral α Modalidad tratamiento Medicamento Nanogel Osteopenia Péptido Pérdida substancia hueso Poliósido Prevención Estabilidad Tecnología farmacéutica Vector medicamento Vía administración Citoquina Sistema osteoarticular patología Propiedad fisicoquímica
Classification
Pascal
002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02A General pharmacology / 002B02A03 Pharmaceutical technology. Pharmaceutical industry

Discipline
General pharmacology
Origin
Inist-CNRS
Database
PASCAL
INIST identifier
21386574

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS

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