Synthesis and evaluation of 2,7-diamino-thiazolo[4,5-d] pyrimidine analogues as anti-tumor epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors
- Author
- RONGHUI LIN1 ; JOHNSON, Sigmond G1 ; FUENTES-PESQUERA, Angel R1 ; MIDDLETON, Steven A1 ; CONNOLLY, Peter J1 ; WETTER, Steven K1 ; BINNUN, Eva1 ; HUGHES, Terry V1 ; MURRAY, William V1 ; PANDEY, Niranjan B1 ; MORENO-MAZZA, Sandra J1 ; ADAMS, Mary1
[1] Johnson & Johnson Pharmaceutical Research & Development LL.C. 1000 Route 202, Raritan, NJ 08869, United States - Source
Bioorganic & medicinal chemistry letters (Print). 2009, Vol 19, Num 8, pp 2333-2337, 5 p ; ref : 12 ref
- ISSN
- 0960-894X
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Amsterdam
- Publication country
- Netherlands
- Document type
- Article
- Language
- English
- Author keyword
- 2,7-Diamino-thiazolo[4,5-d]pyrimidine EGFR inhibitors Epidermal growth factor receptor tyrosine analogues kinase inhibitors
- Keyword (fr)
- Animal Anticancéreux Biodisponibilité Cellule tumorale Composé bicyclique Cytotoxicité Dérivé de la morpholine Dérivé de la pyrrolidine Dérivé du benzène Homme Hétérocycle soufre azote In vitro In vivo Inhibiteur enzyme Lignée cellulaire Ovaire Pharmacocinétique Rat Relation structure activité Récepteur facteur croissance épiderme Souris Sulfonamide Synthèse chimique Transduction signal Transferases Voie intraveineuse Voie orale Lignée SKOV3 Receptor protein-tyrosine kinase Thiazolo[4,5-d]pyrimidine dérivé Thiazolopyrimidine Chlore Composé organique Enzyme Fluor Composé organique Mammalia Rodentia Vertebrata
- Keyword (en)
- Animal Antineoplastic agent Bioavailability Tumor cell Bicyclic compound Cytotoxicity Morpholine derivatives Pyrrolidine derivatives Benzene derivatives Human Sulfur nitrogen heterocycle In vitro In vivo Enzyme inhibitor Cell line Ovary Pharmacokinetics Rat Structure activity relation Epidermal growth factor receptor Mouse Sulfonamide Chemical synthesis Signal transduction Transferases Intravenous administration Oral administration Chlorine Organic compounds Enzyme Fluorine Organic compounds Mammalia Rodentia Vertebrata
- Keyword (es)
- Animal Anticanceroso Biodisponibilidad Célula tumoral Compuesto bicíclico Citotoxicidad Benceno derivado Hombre Heterociclo azufre nitrógeno In vitro In vivo Inhibidor enzima Línea celular Ovario Farmacocinética Rata Relación estructura actividad Receptor del factor de crecimiento epidérmico Ratón Sulfonamida Síntesis química Transducción señal Transferases Vía intravenosa Vía oral Cloro Compuesto orgánico Enzima Fluor Compuesto orgánico Mammalia Rodentia Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R01 General aspects
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 21391813
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmcl.2009.02.067 
https://dx.doi.org/10.1016/j.bmcl.2009.02.067
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