Discovery of oxazolo[4,5-b]pyridines and related heterocyclic analogs as novel SIRT1 activators
- Author
- BEMIS, Jean E1 ; VU, Chi B1 ; SMITH, Jesse J1 ; LAVU, Siva1 ; IFFLAND, Andre1 ; JIROUSEK, Michael R1 ; PERNI, Robert B1 ; ROGER XIE1 ; NUNES, Joseph J1 ; PUI YEE NG1 ; DISCH, Jeremy S1 ; MILNE, Jill C1 ; CARNEY, David P1 ; LYNCH, Amy V1 ; LEI JIN1
[1] Sirtris, A GSK Company, 200 Technology Square, Cambridge, MA 01239, United States - Source
Bioorganic & medicinal chemistry letters (Print). 2009, Vol 19, Num 8, pp 2350-2353, 4 p ; ref : 14 ref
- ISSN
- 0960-894X
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Amsterdam
- Publication country
- Netherlands
- Document type
- Article
- Language
- English
- Author keyword
- SIRT1 activator SIRT1 Sirtuins
- Keyword (fr)
- Activité enzymatique Carboxamide Composé aromatique Composé bicyclique Dérivé de l'imidazopyridine Dérivé de la benzamide Dérivé du benzimidazole Dérivé du stilbène Hydrolases Hétérocycle azote Hétérocycle oxygène azote In vitro Phénols Relation structure activité Resvératrol Synthèse chimique Histone deacetylase Imidazo[4,5-b]pyridine dérivé Oxazolo[4,5-b]pyridine dérivé Oxazolopyridine Quinoxaline-2-carboxamide dérivé Enzyme
- Keyword (en)
- Enzymatic activity Carboxamide Aromatic compound Bicyclic compound Imidazopyridine derivatives Benzamide derivatives Benzimidazole derivatives Stilbene derivatives Hydrolases Nitrogen heterocycle Oxygen nitrogen heterocycle In vitro Phenols Structure activity relation Resveratrol Chemical synthesis Enzyme
- Keyword (es)
- Actividad enzimática Carboxamida Compuesto aromático Compuesto bicíclico Imidazopiridina derivado Benzamida derivado Benzimidazol derivado Estilbeno derivado Hydrolases Heterociclo nitrógeno Heterociclo oxígeno nitrógeno In vitro Fenoles Relación estructura actividad Resveratrol Síntesis química Enzima
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02N General and cellular metabolism. Vitamins
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 21391817
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmcl.2008.11.106 
https://dx.doi.org/10.1016/j.bmcl.2008.11.106
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