PTEN Expression and KRAS Mutations on Primary Tumors and Metastases in the Prediction of Benefit From Cetuximab Plus Irinotecan for Patients With Metastatic Colorectal Cancer
- Author
- LOUPAKIS, Fotios; POLLINA, Luca; CANESTRARI, Emanuele; FUNEL, Niccola; SCHIAVON, Gaia; PETRINI, Iacopo; MAGNANI, Mauro; TONINI, Giuseppe; CAMPANI, Daniela; FLORIANI, Irene; CASCINU, Stefano; FALCONE, Alfredo; STASI, Irene; RUZZO, Annamaria; SCARTOZZI, Mario; SANTINI, Daniele; MASI, Gianluca; GRAZIANO, Francesco; CREMOLINI, Chiara; RULLI, Eliana
[1] Department of Oncology, Azienda Unità Sanitaria Locale 6, Istituto Toscano Tumori, Livorno, Italy
[2] Division of Pathology University of Pisa, Italy
[3] Medical Oncology Unit, Azienda Ospedaliero-Universitaria and University of Pisa, Italy
[4] Department of Oncology, Transplants and New Technologies in Medicine, University of Pisa, Pisa, Italy
[5] Department of Biomolecular Sciences, University of Urbino, Urbino, Italy
[6] Clinica di Oncologia Medica, Azienda Ospedaliera Ospedali Riuniti, Università Politecnica delle Marche, Ancona, Italy
[7] Medical Oncology Unit, University Campus Biomedico, Rome, Italy
[8] Medical Oncology Unit, San Salvatore Hospital, Pesaro, Italy
[9] Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy - Source
Journal of clinical oncology. 2009, Vol 27, Num 16, pp 2622-2629, 8 p ; ref : 41 ref
- ISSN
- 0732-183X
- Scientific domain
- Medical oncology
- Publisher
- American Society of Clinical Oncology, Alexandria, VA
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Anticancéreux Cancer colorectal Cancérologie Cétuximab Facteur prédictif Gène K ras Gène PTEN Gène onc cellulaire Gène suppresseur tumeur Génétique Homme Irinotécan Mutation Métastase Primaire Protooncogène Stade avancé Anti-EGFR Anticorps monoclonal Camptothécine dérivé Cancer DNA topoisomerase Enzyme Inhibiteur de la topoisomérase I Inhibiteur enzyme Isomerases Pathologie de l'appareil digestif Pathologie de l'intestin Pathologie du côlon Pathologie du rectum Récepteur facteur croissance épiderme Tumeur maligne
- Keyword (en)
- Antineoplastic agent Colorectal cancer Cancerology Cetuximab Predictive factor K ras Gene PTEN Gene C-Onc gene Tumor suppressor gene Genetics Human Irinotecan Mutation Metastasis Primary Protooncogene Advanced stage Monoclonal antibody Camptothecin derivatives Cancer DNA topoisomerase Enzyme Topoisomerase I inhibitor Enzyme inhibitor Isomerases Digestive diseases Intestinal disease Colonic disease Rectal disease Epidermal growth factor receptor Malignant tumor
- Keyword (es)
- Anticanceroso Cancer de colon y recto Cancerología Cetuximab Factor predictivo Gen K ras Gen PTEN Gen onc celular Gen supresor tumor Genética Hombre Irinotecán Mutación Metástasis Primario Protooncogen Estadio avanzado Anticuerpo monoclonal Camptothecin derivado Cáncer DNA topoisomerase Enzima Inhibidor topoisomerase I Inhibidor enzima Isomerases Aparato digestivo patología Intestino patología Colón patología Recto patología Receptor del factor de crecimiento epidérmico Tumor maligno
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B13 Gastroenterology. Liver. Pancreas. Abdomen / 002B13B Stomach. Duodenum. Small intestine. Colon. Rectum. Anus / 002B13B01 Tumors
- Discipline
- Gastroenterology. Liver. Pancreas. Abdomen Tumours
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 21538387
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1200/JCO.2008.20.2796 
https://dx.doi.org/10.1200/JCO.2008.20.2796
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