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Population Pharmacokinetics of Lopinavir Predict Suboptimal Therapeutic Concentrations in Treatment-Experienced Human Immunodeficiency Virus-Infected Children

Author
RAKHMANINA, Natella1 2 4 ; VAN DEN ANKER, John1 2 5 6 ; BAGHDASSARIAN, Aline4 ; SOLDIN, Steven3 4 5 7 ; WILLIAM, Keetra1 ; NEELY, Michael N8 9
[1] Division of Infectious Disease, Children's National Medical Center, Washington, DC, United States
[2] Division of Pediatric Clinical Pharmacology, Children's National Medical Center, Washington, DC, United States
[3] Department of Laboratory Medicine, Children's National Medical Center, Washington, DC, United States
[4] Department of Pediatrics, George Washington University School of Medicine, Washington, DC, United States
[5] Department of Pathology, George Washington University School of Medicine, Washington, DC, United States
[6] Pharmacology and Department of Physiology, George Washington University School of Medicine, Washington, DC, United States
[7] Department of Pharmacology, Georgetown University and Georgetown Clinical Research Center, Washington, DC, United States
[8] Division of Pediatric Infectious Diseases, University of Southern California, Los Angeles, California, United States
[9] Laboratory of Applied Pharmacokinetics, University of Southern California, Los Angeles, California, United States
Source

Antimicrobial agents and chemotherapy. 2009, Vol 53, Num 6, pp 2532-2538, 7 p ; ref : 28 ref

CODEN
AACHAX
ISSN
0066-4804
Scientific domain
Microbiology, infectious diseases; Pharmacology drugs
Publisher
American Society for Microbiology, Washington, DC
Publication country
United States
Document type
Article
Language
English
Keyword (fr)
Antirétroviral Antiviral Concentration Enfant Facteur prédictif Lopinavir Pharmacocinétique de la population SIDA Traitement Enzyme Homme Hydrolases Immunodéficit Immunopathologie Infection Inhibiteur enzyme Inhibiteur protease Peptidases Virose
Keyword (en)
Antiretroviral agent Antiviral Concentration Child Predictive factor Lopinavir Population pharmacokinetics AIDS Treatment Enzyme Human Hydrolases Immune deficiency Immunopathology Infection Enzyme inhibitor Protease inhibitor Peptidases Viral disease
Keyword (es)
Antiretroviral Antiviral Concentración Niño Factor predictivo Lopinavir Farmacocinética población SIDA Tratamiento Enzima Hombre Hydrolases Inmunodeficiencia Inmunopatología Infección Inhibidor enzima Inhibidor proteasa Peptidases Virosis
Classification
Pascal
002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02S Antibiotics. Antiinfectious agents. Antiparasitic agents

Pascal
002 Biological and medical sciences / 002B Medical sciences / 002B05 Infectious diseases / 002B05C Viral diseases / 002B05C02 Human viral diseases / 002B05C02D Viral diseases of the lymphoid tissue and the blood. Aids

Pascal
002 Biological and medical sciences / 002B Medical sciences / 002B06 Immunopathology / 002B06D Immunodeficiencies. Immunoglobulinopathies / 002B06D01 Immunodeficiencies

Discipline
Immunopathology Infectious pathology Pharmacological treatments
Origin
Inist-CNRS
Database
PASCAL
INIST identifier
21538681

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS

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