Novel non-peptide β-secretase inhibitors derived from structure-based virtual screening and bioassay
- Author
- WEIJUN XU1 ; GANG CHEN2 ; OI WAH LIEW2 ; ZHILI ZUO2 3 ; HUALIANG JIANG4 ; WEILIANG ZHU4
[1] School of Chemical and Life Sciences, Singapore Polytechnic, Singapore 139651, Singapore
[2] Centre for Biomedical and Life Sciences, Singapore Polytechnic, Singapore 139651, Singapore
[3] School of Biomedical Sciences, Curtin University of Technology, Perth, WA 6485, Australia
[4] Drug Discovery and Design Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China - Source
Bioorganic & medicinal chemistry letters (Print). 2009, Vol 19, Num 12, pp 3188-3192, 5 p
- ISSN
- 0960-894X
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Amsterdam
- Publication country
- Netherlands
- Document type
- Article
- Language
- English
- Author keyword
- Bioassay FRET Virtual screening β-Secretase
- Keyword (fr)
- Antialzheimer Aspartic endopeptidases Composé non peptide Criblage virtuel Dérivé de la pipéridine Dérivé du benzothiazole Essai biologique Inhibiteur enzyme Mode liaison Modèle moléculaire Modélisation Protéine précurseur amyloïde Relation structure activité Spectrométrie fluorescence Transfert énergie résonnant β-secretase 1,3,5-Triazine dérivé Acétamide dérivé Inhibiteur BACE Enzyme Hydrolases Peptidases
- Keyword (en)
- Antialzheimer agent Aspartic endopeptidases Non peptide compound Virtual screening Piperidine derivatives Benzothiazole derivatives Bioassay Enzyme inhibitor Binding mode Molecular model Modeling Amyloid precursor protein Structure activity relation Fluorescence spectrometry Resonant energy transfer β-secretase Enzyme Hydrolases Peptidases
- Keyword (es)
- Antialzheimer Aspartic endopeptidases Compuesto no péptido Cribado virtual Piperidina derivado Benzotiazol derivado Prueba biológica Inhibidor enzima Modo de enlace Modelo molecular Modelización Proteína precursor amiloide Relación estructura actividad Espectrometría fluorescencia Transferencia energía resonante β-secretase Enzima Hydrolases Peptidases
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02B Neuropharmacology / 002B02B02 Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)
- Francis
- 770 Psychology. Psychoanalysis. Psychiatry / 770-E Psychopharmacology / 770-E02 Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer…
- Discipline
- Pharmacological treatments Psychopathology. Psychiatry. Clinical psychology
- Origin
- Inist-CNRS
- Database
- FRANCIS ; PASCAL
- INIST identifier
- 21589316
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmcl.2009.04.113 
https://dx.doi.org/10.1016/j.bmcl.2009.04.113
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