Design and optimization of renin inhibitors: Orally bioavailable alkyl amines
- Author
- TICE, Colin M1 ; ZHENRONG XU1 ; ZHONGREN WU1 ; SCOTT, Boyd B1 ; BUKHTIYAROV, Yuri1 ; BERBAUM, Jennifer1 ; MASON, Jennifer1 ; PANEMANGALORE, Reshma1 ; GRAZIA CAPPIELLO, Maria1 ; MÜLLER, Dominik2 ; HARRISON, Richard K1 ; MCGEEHAN, Gerard M1 ; JING YUAN1 ; DILLARD, Lawrence W; BALDWIN, John J; CLAREMON, David A; SIMPSON, Robert D1 ; CACATIAN, Salvacion T1 ; FLAHERTY, Patrick T1 ; WEI ZHAO1 ; JOAN GUO1 ; ISHCHENKO, Alexey1 ; SINGH, Suresh B1
[1] Vitae Pharmaceuticals, 502 West Office Center Drive, Fort Washington, PA 19034, United States
[2] Charité Berlin, Dept of Pediatric Nephrology, Augustenburger Platz 1, 13353 Berlin, Germany - Source
Bioorganic & medicinal chemistry letters (Print). 2009, Vol 19, Num 13, pp 3541-3545, 5 p
- ISSN
- 0960-894X
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Amsterdam
- Publication country
- Netherlands
- Document type
- Article
- Language
- English
- Author keyword
- Antihypertensive Aspartyl protease Renin Structure based drug design
- Keyword (fr)
- Alcool tertiaire Amine secondaire Amine Animal Antihypertenseur Biodisponibilité Chlore Composé organique Dérivé de la pipéridine Dérivé du cyclohexane Inhibiteur enzyme Optimisation Pharmacocinétique Rat Relation structure activité Renin Synthèse chimique Urées Voie orale Inhibiteur renin Aspartic endopeptidases Enzyme Hydrolases Mammalia Peptidases Rodentia Vertebrata
- Keyword (en)
- Tertiary alcohol Secondary amine Amine Animal Antihypertensive agent Bioavailability Chlorine Organic compounds Piperidine derivatives Cyclohexane derivatives Enzyme inhibitor Optimization Pharmacokinetics Rat Structure activity relation Renin Chemical synthesis Ureas Oral administration Aspartic endopeptidases Enzyme Hydrolases Mammalia Peptidases Rodentia Vertebrata
- Keyword (es)
- Alcohol terciario Amina secundaria Amina Animal Antihipertensivo Biodisponibilidad Cloro Compuesto orgánico Piperidina derivado Ciclohexano derivado Inhibidor enzima Optimización Farmacocinética Rata Relación estructura actividad Renin Síntesis química Ureas Vía oral Aspartic endopeptidases Enzima Hydrolases Mammalia Peptidases Rodentia Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02F Cardiovascular system / 002B02F05 Antihypertensive agents
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 21650120
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmcl.2009.04.140 
https://dx.doi.org/10.1016/j.bmcl.2009.04.140
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